Glucocorticoids suppress early lung inflammation and impair control of SARS-CoV-2 in non-human primates

• Christine E. Nelson,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Current address: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA, USA

  Affiliation T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0003-3879-9105

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• Keith D. Kauffman,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Shunsuke Sakai,

  Roles Investigation, Writing – review & editing

  Affiliation T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Taylor Newbolt,

  Roles Investigation, Writing – review & editing

  Current address: Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

  Affiliation T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0009-0002-7503-4267

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• Jay Buchanan,

  Roles Investigation, Writing – review & editing

  Affiliation T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Taylor W. Foreman,

  Roles Investigation, Writing – review & editing

  Affiliation T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• April M. Walker,

  Roles Investigation, Writing – review & editing

  Affiliation Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Felipe Gomez,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Joel D. Fleegle,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Tuberculosis Imaging Program ,

  ¶Membership of the Tuberculosis Imaging Program is provided in the Acknowledgements.

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• Richard Herbert,

  Roles Methodology, Writing – review & editing

  Affiliation Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Tom Hill,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Integrated Data Science Section, Research Technologies Branch, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-4661-6391

  ⨯
• Sevilay Turan,

  Roles Investigation, Writing – review & editing

  Affiliation Leidos Biomedical Sciences Inc, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

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• Katrin D. Mayer-Barber,

  Roles Resources, Writing – review & editing

  Affiliation Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Reed F. Johnson,

  Roles Methodology, Writing – review & editing

  Current address: National Bio and Agro-Defense Facility, U.S. Department of Agriculture, Manhattan, KS, USA

  Affiliation SARS-CoV-2 Virology Core, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Laura E. Via,

  Roles Formal analysis, Investigation, Supervision, Writing – review & editing

  Affiliations Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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•  [ ... ],
• Daniel L. Barber

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: barberd@nih.gov

  Affiliation T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0001-7008-7509

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