Combining transcranial direct current stimulation and computerized cognitive training for post-stroke cognitive recovery: Study protocol for a randomized controlled trial with optimized temporal intervention sequences

Xinling Wei; Jianwei Xia; Rui Luo; Peng Hu; Yuanyuan Wu; Jia Liu; Luping Song; Naifu Jiang; Minghong Sui

doi:10.1371/journal.pone.0342761

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Combining transcranial direct current stimulation and computerized cognitive training for post-stroke cognitive recovery: Study protocol for a randomized controlled trial with optimized temporal intervention sequences

Xinling Wei,

Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Rehabilitation College, Gannan Medical University, Jiangxi, China
⨯
Jianwei Xia,

Roles Data curation

Affiliation School of Special Education and Rehabilitation, Binzhou Medical University, Yantai, China
⨯
Rui Luo,

Roles Investigation

Affiliation Department of Medicine, Shenzhen University, Shenzhen, China
⨯
Peng Hu,

Roles Investigation

Affiliation Department of Medicine, Shenzhen University, Shenzhen, China
⨯
Yuanyuan Wu,

Roles Investigation

Affiliation Clinical College, Youjiang Medical University For Nationalities, Baise, China
⨯
Jia Liu,

Roles Data curation

Affiliation Rehabilitation Medicine Department, Shenzhen Nanshan People’s Hospital(Shenzhen Sixth People’s Hospital), Shenzhen, China
⨯
Luping Song,

Roles Data curation, Funding acquisition

Affiliation Rehabilitation Medicine Department, Shenzhen Nanshan People’s Hospital(Shenzhen Sixth People’s Hospital), Shenzhen, China
⨯
Naifu Jiang ,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

* E-mail: meekoosan@163.com (MHS), nf.jiang@siat.ac.cn (NFJ)

Affiliation Guangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Shenzhen, China
⨯
Minghong Sui

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: meekoosan@163.com (MHS), nf.jiang@siat.ac.cn (NFJ)

Affiliation Rehabilitation Medicine Department, Shenzhen Nanshan People’s Hospital(Shenzhen Sixth People’s Hospital), Shenzhen, China

https://orcid.org/0009-0009-7820-1527

⨯

Combining transcranial direct current stimulation and computerized cognitive training for post-stroke cognitive recovery: Study protocol for a randomized controlled trial with optimized temporal intervention sequences

Xinling Wei,
Jianwei Xia,
Rui Luo,
Peng Hu,
Yuanyuan Wu,
Jia Liu,
Luping Song,
Naifu Jiang,
Minghong Sui

Published: March 4, 2026
https://doi.org/10.1371/journal.pone.0342761

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Transcranial direct-current stimulation
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Cognitive impairment
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Adverse events
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Prefrontal cortex
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Stroke
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Neuronal plasticity
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Computer software
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