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Open Access

Peer-reviewed

Research Article

KPC-33 and ompK37 mutations: Unraveling the mechanism of ceftazidime/avibactam resistance in ST11 carbapenem-resistant Klebsiella pneumoniae

Shulong Zhao ,

Contributed equally to this work with: Shulong Zhao, Lin Ye

Roles Writing – original draft

Affiliation Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China

https://orcid.org/0000-0001-6334-7296

⨯
Lin Ye ,

Contributed equally to this work with: Shulong Zhao, Lin Ye

Roles Writing – original draft

Affiliation Medical Technology School, Xuzhou Medical University, Xuzhou, Jiangsu, China
⨯
Shuang Song,

Roles Data curation

Affiliation Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
⨯
Jingfang Sun,

Roles Data curation

Affiliation Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
⨯
Jinfeng Xu,

Roles Formal analysis

Affiliation Department of Clinical Laboratory, Zhenjiang Center for Disease Control and Prevention, Zhenjiang, Jiangsu, China
⨯
Fei Jiang ,

Roles Writing – review & editing

* E-mail: hqk811029@163.com (HK); jiangf0319@126.com (FJ)

Affiliation Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
⨯
Haiquan Kang

Roles Writing – review & editing

* E-mail: hqk811029@163.com (HK); jiangf0319@126.com (FJ)

Affiliations Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China, Medical Technology School, Xuzhou Medical University, Xuzhou, Jiangsu, China
⨯

KPC-33 and ompK37 mutations: Unraveling the mechanism of ceftazidime/avibactam resistance in ST11 carbapenem-resistant Klebsiella pneumoniae

Shulong Zhao,
Lin Ye,
Shuang Song,
Jingfang Sun,
Jinfeng Xu,
Fei Jiang,
Haiquan Kang

x

Published: March 2, 2026
https://doi.org/10.1371/journal.pone.0342729

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Klebsiella pneumoniae
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China
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Broth microdilution
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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
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Plasmids
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Escherichia coli
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Genomics
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Polymyxins
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