SHP2 improved Late-onset fetal growth restriction via modulating ROS/BRD4/PI3K/YAP/PIGF signaling induced angiogenesis

Fang Li; Yaqin Li; Wei Hao; Xuan Zhang; Xueyan Shen; Botao Yang; Wei Zhang; Liman Fu; Suyan Gu

doi:10.1371/journal.pone.0342649

Loading metrics

Open Access

Peer-reviewed

Research Article

SHP2 improved Late-onset fetal growth restriction via modulating ROS/BRD4/PI3K/YAP/PIGF signaling induced angiogenesis

Fang Li,

Roles Conceptualization, Data curation, Writing – original draft

Affiliation Department of Obstetrics, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, China
⨯
Yaqin Li,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Obstetrics, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, China
⨯
Wei Hao,

Roles Formal analysis, Investigation, Project administration, Writing – original draft

Affiliation Health Commission of Hebei Province, Shijiazhuang, China
⨯
Xuan Zhang,

Roles Investigation, Project administration, Resources

Affiliation Department of Obstetrics, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, China
⨯
Xueyan Shen,

Roles Investigation, Supervision, Writing – original draft

Affiliation Department of Obstetrics, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, China
⨯
Botao Yang,

Roles Project administration, Software, Writing – review & editing

Affiliation Department of Obstetrics, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, China
⨯
Wei Zhang,

Roles Methodology, Resources, Software

Affiliation Department of Obstetrics, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, China
⨯
Liman Fu,

Roles Formal analysis, Methodology, Validation

Affiliation Department of Obstetrics, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, China
⨯
Suyan Gu

Roles Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

* E-mail: Shizicaihong123@163.com

Affiliation Department of Obstetrics, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, China

https://orcid.org/0009-0005-4714-484X

⨯

SHP2 improved Late-onset fetal growth restriction via modulating ROS/BRD4/PI3K/YAP/PIGF signaling induced angiogenesis

Fang Li,
Yaqin Li,
Wei Hao,
Xuan Zhang,
Xueyan Shen,
Botao Yang,
Wei Zhang,
Liman Fu,
Suyan Gu

Published: February 13, 2026
https://doi.org/10.1371/journal.pone.0342649

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Angiogenesis
Is the Subject Area "Angiogenesis" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Stress signaling cascade
Is the Subject Area "Stress signaling cascade" applicable to this article?

Thanks for your feedback.
Oxidative stress
Is the Subject Area "Oxidative stress" applicable to this article?

Thanks for your feedback.
Stem cells
Is the Subject Area "Stem cells" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Bioinformatics
Is the Subject Area "Bioinformatics" applicable to this article?

Thanks for your feedback.