Evidence for genetic correlation between appendix and inflammatory bowel disease: A bidirectional Mendelian randomization study

Dan Liu; Wanyue Dan; Bin Yan; Lihua Peng; Fei Pan

doi:10.1371/journal.pone.0342541

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Open Access

Peer-reviewed

Research Article

Evidence for genetic correlation between appendix and inflammatory bowel disease: A bidirectional Mendelian randomization study

Dan Liu ,

Roles Conceptualization, Data curation, Writing – original draft

¶☯ These authors contributed equally to this work and share first authorship

Affiliations School of Medicine, Nankai University, Tianjin, China, Department of Gastroenterology and Hepatology, the First Medical Center, Chinese PLA General Hospital, Beijing, China
⨯
Wanyue Dan ,

Roles Conceptualization, Writing – original draft, Writing – review & editing

¶☯ These authors contributed equally to this work and share first authorship

Affiliations School of Medicine, Nankai University, Tianjin, China, Department of Gastroenterology and Hepatology, the First Medical Center, Chinese PLA General Hospital, Beijing, China
⨯
Bin Yan,

Roles Supervision

Affiliation Department of Gastroenterology and Hepatology, the First Medical Center, Chinese PLA General Hospital, Beijing, China
⨯
Lihua Peng ,

Roles Investigation, Supervision

* E-mail: penglihua301@126.com (LP); panfei@plagh.org (FP)

Affiliations School of Medicine, Nankai University, Tianjin, China, Department of Gastroenterology and Hepatology, the First Medical Center, Chinese PLA General Hospital, Beijing, China
⨯
Fei Pan

Roles Conceptualization, Investigation, Supervision

* E-mail: penglihua301@126.com (LP); panfei@plagh.org (FP)

Affiliations School of Medicine, Nankai University, Tianjin, China, Department of Gastroenterology and Hepatology, the First Medical Center, Chinese PLA General Hospital, Beijing, China

https://orcid.org/0000-0002-3307-7931

⨯

Evidence for genetic correlation between appendix and inflammatory bowel disease: A bidirectional Mendelian randomization study

Dan Liu,
Wanyue Dan,
Bin Yan,
Lihua Peng,
Fei Pan

Published: February 11, 2026
https://doi.org/10.1371/journal.pone.0342541

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Appendicitis
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Appendectomy
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Ulcerative colitis
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Inflammatory bowel disease
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