A phase I clinical trial to evaluate the tolerability and safety of an allogeneic iPSC-derived iNKT cell and α-GalCer-pulsed autologous DC combination therapy for patients with recurrent and advanced head and neck cancer: A study protocol

• Tomoya Kurokawa,

  Roles Conceptualization, Writing – original draft

  Affiliations Clinical Research Center, Chiba University Hospital, Chiba, Chiba, Japan, Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan

  https://orcid.org/0009-0002-8996-4676

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• Tomohisa Iinuma,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan

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• Haruna Ebisu,

  Roles Project administration

  Affiliation Clinical Research Center, Chiba University Hospital, Chiba, Chiba, Japan

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• Tomoha Yanagidaira,

  Roles Project administration

  Affiliation Clinical Research Center, Chiba University Hospital, Chiba, Chiba, Japan

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• Yosuke Inaba,

  Roles Formal analysis

  Affiliation Clinical Research Center, Chiba University Hospital, Chiba, Chiba, Japan

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• Tadami Fujiwara,

  Roles Project administration, Writing – review & editing

  Affiliation Clinical Research Center, Chiba University Hospital, Chiba, Chiba, Japan

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• Yoko Hattori,

  Roles Data curation

  Affiliation Clinical Research Center, Chiba University Hospital, Chiba, Chiba, Japan

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• Tominaga Fukazawa,

  Roles Project administration

  Affiliation Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan

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• Takahiro Aoki,

  Roles Investigation

  Affiliations Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan, Department of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan

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• Haruhiko Koseki,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan

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• Hideki Hanaoka,

  Roles Supervision

  Affiliation Clinical Research Center, Chiba University Hospital, Chiba, Chiba, Japan

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• Toyoyuki Hanazawa,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan

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• Shinichiro Motohashi

  Roles Conceptualization, Supervision, Writing – review & editing

  * E-mail: motohashi@faculty.chiba-u.jp

  Affiliation Department of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan

  https://orcid.org/0000-0002-9332-3129

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