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Open Access
Study Protocol
Study protocol for a multicenter phase II prospective externally controlled non-inferiority trial of hypofractionated re-irradiation in patients with recurrent high-grade glioma (RISinG)
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A. M. de Jong ,
Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing
* E-mail: a.m.dejong-42@umcutrecht.nl
Affiliations Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands, Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands
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A. T. J. van der Boog,
Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands, Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands
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C. C. B. Post,
Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands
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F. Cialdella,
Roles Investigation, Writing – review & editing
Affiliations Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands, Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands
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D. B. P. Eekers,
Roles Investigation, Resources, Validation, Writing – review & editing
Affiliation Department of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, the Netherlands
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J. Hendrikse,
Roles Conceptualization, Investigation, Methodology, Writing – review & editing
Affiliation Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands
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M. C. A. Kramer,
Roles Conceptualization, Investigation, Methodology, Resources, Validation, Writing – original draft, Writing – review & editing
Affiliation Department of Radiation Oncology, University Medical Center Groningen, Groningen, the Netherlands
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F. J. Lagerwaard ,
Roles Conceptualization, Investigation, Methodology, Writing – original draft
¶† Deceased
Affiliation Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, the Netherlands
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M. van der Meulen,
Roles Conceptualization, Investigation, Validation, Writing – review & editing
Affiliation Department of Neurology, Medisch Spectrum Twente, Enschede/ department of Neurology Leiden University Medical Center, Leiden, the Netherlands
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M. E. P. Philippens,
Roles Conceptualization, Investigation, Validation, Writing – review & editing
Affiliation Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands
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P. A. Robe,
Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands
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T. Rozema,
Roles Investigation, Resources, Writing – review & editing
Affiliation Department of Radiation Oncology, Instituut Verbeeten, Tilburg, the Netherlands
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F. Y. F. L. de Vos,
Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands
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J. Vos-Westerman,
Roles Investigation, Resources, Writing – review & editing
Affiliation Department of Radiation Oncology, Isala Klinieken, Zwolle, the Netherlands
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H. L. van der Weide,
Roles Investigation, Resources, Writing – review & editing
Affiliation Department of Radiation Oncology, University Medical Center Groningen, Groningen, the Netherlands
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G. Wester,
Roles Investigation, Resources, Writing – review & editing
Affiliation Department of Radiation Oncology, Radiotherapiegroep Arnhem, Apeldoorn, Deventer, Ede, the Netherlands
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J. Zindler,
Roles Investigation, Resources, Writing – review & editing
Affiliation Department of Radiation Oncology, Haaglanden Medisch Centrum, Den Haag, the Netherlands
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T. J. Snijders,
Roles Conceptualization, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing
Affiliation Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands
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J. J. C. Verhoeff
Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliations Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands, Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, the Netherlands
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Study protocol for a multicenter phase II prospective externally controlled non-inferiority trial of hypofractionated re-irradiation in patients with recurrent high-grade glioma (RISinG)
- A. M. de Jong,
- A. T. J. van der Boog,
- C. C. B. Post,
- F. Cialdella,
- D. B. P. Eekers,
- J. Hendrikse,
- M. C. A. Kramer,
- F. J. Lagerwaard,
- M. van der Meulen,
- M. E. P. Philippens
- Published: February 9, 2026
- https://doi.org/10.1371/journal.pone.0342337