IL-22 inhibits ferroptosis and attenuates ischemia-reperfusion-induced acute kidney injury: Association with activation of the P62-Keap1-Nrf2 signaling pathway

Lin Zhang; Feng Luo; Yalin Chai; Lijie Sun; Xuan Wang; Le Yin; Congjuan Luo

doi:10.1371/journal.pone.0342335

Loading metrics

Open Access

Peer-reviewed

Research Article

IL-22 inhibits ferroptosis and attenuates ischemia-reperfusion-induced acute kidney injury: Association with activation of the P62-Keap1-Nrf2 signaling pathway

Lin Zhang,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China
⨯
Feng Luo ,

Roles Conceptualization, Software, Supervision, Visualization

* E-mail: luofeng19821124@126.com (FL); luocongjuan2018@163.com (CL)

Affiliation Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China
⨯
Yalin Chai,

Roles Formal analysis, Validation, Visualization

Affiliation Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China
⨯
Lijie Sun,

Roles Software, Visualization

Affiliation Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China
⨯
Xuan Wang,

Roles Conceptualization, Visualization

Affiliation Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China
⨯
Le Yin,

Roles Software, Visualization

Affiliation Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China
⨯
Congjuan Luo

Roles Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: luofeng19821124@126.com (FL); luocongjuan2018@163.com (CL)

Affiliation Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China

https://orcid.org/0000-0003-1952-8668

⨯

IL-22 inhibits ferroptosis and attenuates ischemia-reperfusion-induced acute kidney injury: Association with activation of the P62-Keap1-Nrf2 signaling pathway

Lin Zhang,
Feng Luo,
Yalin Chai,
Lijie Sun,
Xuan Wang,
Le Yin,
Congjuan Luo

Published: February 6, 2026
https://doi.org/10.1371/journal.pone.0342335

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Kidneys
Is the Subject Area "Kidneys" applicable to this article?

Thanks for your feedback.
Renal system
Is the Subject Area "Renal system" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Renal ischemia
Is the Subject Area "Renal ischemia" applicable to this article?

Thanks for your feedback.
Epithelial cells
Is the Subject Area "Epithelial cells" applicable to this article?

Thanks for your feedback.
Lipid peroxidation
Is the Subject Area "Lipid peroxidation" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.