Higher order synthetic lethals are keys to minimize cancer treatment effects on non-tumor cells

• Mehdi Dehghan Manshadi,

  Roles Formal analysis, Methodology, Software, Visualization, Writing – original draft

  Affiliations Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden, Algorithmic Dynamics Lab, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden, Department of Chemical Engineering, School of Chemical, Petroleum and Gas Engineering, Shiraz University, Shiraz, Iran

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• Payam Setoodeh ,

  Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: payamst@shirazu.ac.ir, setoodep@mcmaster.ca (PS); rajaba@mcmaster.ca (ARR); zare@uthscsa.edu (HZ)

  Affiliations Department of Chemical Engineering, School of Chemical, Petroleum and Gas Engineering, Shiraz University, Shiraz, Iran, W Booth School of Engineering Practice and Technology, McMaster University, Hamilton, Ontario, Canada

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• Amin Ramezani,

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliations Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

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• Amin Reza Rajabzadeh ,

  Roles Project administration, Writing – review & editing

  * E-mail: payamst@shirazu.ac.ir, setoodep@mcmaster.ca (PS); rajaba@mcmaster.ca (ARR); zare@uthscsa.edu (HZ)

  ¶☯ These authors contributed equally as the co-senior authors.

  Affiliations W Booth School of Engineering Practice and Technology, McMaster University, Hamilton, Ontario, Canada, School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada

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• Habil Zare

  Roles Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: payamst@shirazu.ac.ir, setoodep@mcmaster.ca (PS); rajaba@mcmaster.ca (ARR); zare@uthscsa.edu (HZ)

  ¶☯ These authors contributed equally as the co-senior authors.

  Affiliation Haba Businesses, San Antonio, Texas, United States of America

  https://orcid.org/0000-0001-5902-6238

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