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Open Access

Peer-reviewed

Research Article

Kisspeptin improves local ovarian insulin resistance in PCOS by modulating the PI3K/AKT/GLUT4 signaling pathway

Na Sun,

Roles Writing – original draft, Writing – review & editing

Affiliation Reproductive Medicine Center, Weifang People’s Hospital, Weifang, Shandong Province, China
⨯
Pingping Sun,

Roles Writing – original draft

Affiliation Reproductive Medicine Center, Weifang People’s Hospital, Weifang, Shandong Province, China
⨯
Lilan Sun,

Roles Writing – original draft

Affiliation Reproductive Medicine Center, Weifang People’s Hospital, Weifang, Shandong Province, China
⨯
Ping Sun,

Roles Writing – original draft

Affiliation Reproductive Medicine Center, Weifang People’s Hospital, Weifang, Shandong Province, China
⨯
Dandan Qi,

Roles Writing – original draft

Affiliation Reproductive Medicine Center, Weifang People’s Hospital, Weifang, Shandong Province, China
⨯
Huagang Ma

Roles Writing – original draft, Writing – review & editing

* E-mail: mahuagang8192693@163.com

Affiliation Reproductive Medicine Center, Weifang People’s Hospital, Weifang, Shandong Province, China

https://orcid.org/0000-0003-3999-1940

⨯

Kisspeptin improves local ovarian insulin resistance in PCOS by modulating the PI3K/AKT/GLUT4 signaling pathway

Na Sun,
Pingping Sun,
Lilan Sun,
Ping Sun,
Dandan Qi,
Huagang Ma

x

Published: February 2, 2026
https://doi.org/10.1371/journal.pone.0342158

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Polycystic ovary syndrome
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Insulin resistance
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Mouse models
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Insulin signaling
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Insulin
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Reactive oxygen species
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