Molecular interplay of ASNS and the PI3K-AKT-mTOR pathway in CMV and HIV co-infections: Therapeutic implications

Hao Zhang; ShuYou Yuan; ShaoXiang Ding; HongXia Bao; WenJun Chen; Bo Cai; JunKai Sun; HaoGang Zhu; Wei Lu; Ye Fang

doi:10.1371/journal.pone.0342050

Loading metrics

Open Access

Peer-reviewed

Research Article

Molecular interplay of ASNS and the PI3K-AKT-mTOR pathway in CMV and HIV co-infections: Therapeutic implications

Hao Zhang ,

Contributed equally to this work with: Hao Zhang, ShuYou Yuan

Roles Formal analysis, Writing – original draft

Affiliation Geriatrics Center, Wuxi Second Geriatric Hospital, Wuxi, Jiangsu, China
⨯
ShuYou Yuan ,

Contributed equally to this work with: Hao Zhang, ShuYou Yuan

Roles Formal analysis, Writing – original draft

Affiliation Laboratory Department, Wuxi Second Geriatric Hospital, Wuxi, Jiangsu, China
⨯
ShaoXiang Ding,

Roles Data curation, Methodology

Affiliation Geriatrics Center, Wuxi Second Geriatric Hospital, Wuxi, Jiangsu, China
⨯
HongXia Bao,

Roles Data curation, Formal analysis

Affiliation Geriatrics Center, Wuxi Second Geriatric Hospital, Wuxi, Jiangsu, China
⨯
WenJun Chen,

Roles Data curation, Formal analysis, Methodology

Affiliation Neurology Department, Wuxi Second Geriatric Hospital, Wuxi, Jiangsu, China
⨯
Bo Cai,

Roles Data curation, Formal analysis, Methodology

Affiliation Pathology Department, Wuxi Second Geriatric Hospital, Wuxi, Jiangsu, China
⨯
JunKai Sun ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: fangye841014@sina.com (YF); luwei5166@gmail.com (WL); 911207258@qq.com (HZ); 854437824@qq.com (JS)

Affiliation Department of Interventional Radiology, Wuxi No. 5 People’s Hospital, Wuxi, Jiangsu, China
⨯
HaoGang Zhu ,

Roles Conceptualization, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: fangye841014@sina.com (YF); luwei5166@gmail.com (WL); 911207258@qq.com (HZ); 854437824@qq.com (JS)

Affiliation Geriatrics Center, Wuxi Second Geriatric Hospital, Wuxi, Jiangsu, China
⨯
Wei Lu ,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

* E-mail: fangye841014@sina.com (YF); luwei5166@gmail.com (WL); 911207258@qq.com (HZ); 854437824@qq.com (JS)

Affiliation Geriatrics Center, Wuxi Second Geriatric Hospital, Wuxi, Jiangsu, China

https://orcid.org/0009-0008-6566-5368

⨯
Ye Fang

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: fangye841014@sina.com (YF); luwei5166@gmail.com (WL); 911207258@qq.com (HZ); 854437824@qq.com (JS)

Affiliation Department of Emergency Medicine, Wuxi People’s Hospital, Wuxi, Jiangsu, China
⨯

Molecular interplay of ASNS and the PI3K-AKT-mTOR pathway in CMV and HIV co-infections: Therapeutic implications

Hao Zhang,
ShuYou Yuan,
ShaoXiang Ding,
HongXia Bao,
WenJun Chen,
Bo Cai,
JunKai Sun,
HaoGang Zhu,
Wei Lu,
Ye Fang

Published: February 20, 2026
https://doi.org/10.1371/journal.pone.0342050

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

HIV
Is the Subject Area "HIV" applicable to this article?

Thanks for your feedback.
HIV infections
Is the Subject Area "HIV infections" applicable to this article?

Thanks for your feedback.
Co-infections
Is the Subject Area "Co-infections" applicable to this article?

Thanks for your feedback.
Hydrogen bonding
Is the Subject Area "Hydrogen bonding" applicable to this article?

Thanks for your feedback.
HIV diagnosis and management
Is the Subject Area "HIV diagnosis and management" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Transcriptional control
Is the Subject Area "Transcriptional control" applicable to this article?

Thanks for your feedback.
Machine learning
Is the Subject Area "Machine learning" applicable to this article?

Thanks for your feedback.