Reducing OGT and O-GlcNAcylation enhance the anticancer effects of oxaliplatin in SW620 metastatic colorectal cancer cells

Thirasak Bunsuk; Juthamard Chantaraamporn; Photsathorn Mutapat; Penchatr Diskul Na Ayudthaya; Daranee Chokchaichamnankit; Chantragan Srisomsap; Jisnuson Svasti; Voraratt Champattanachai

doi:10.1371/journal.pone.0341971

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Open Access

Peer-reviewed

Research Article

Reducing OGT and O-GlcNAcylation enhance the anticancer effects of oxaliplatin in SW620 metastatic colorectal cancer cells

Thirasak Bunsuk ,

Contributed equally to this work with: Thirasak Bunsuk, Juthamard Chantaraamporn

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft

Affiliation Applied Biological Sciences: Environmental Health Program, Chulabhorn Graduate Institute, Bangkok, Thailand
⨯
Juthamard Chantaraamporn ,

Contributed equally to this work with: Thirasak Bunsuk, Juthamard Chantaraamporn

Roles Conceptualization, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

Affiliation Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand
⨯
Photsathorn Mutapat,

Roles Formal analysis, Methodology

Affiliation Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand
⨯
Penchatr Diskul Na Ayudthaya,

Roles Formal analysis, Methodology

Affiliation Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand
⨯
Daranee Chokchaichamnankit,

Roles Formal analysis, Methodology

Affiliation Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand

https://orcid.org/0000-0002-5084-8259

⨯
Chantragan Srisomsap,

Roles Supervision, Writing – review & editing

Affiliation Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand
⨯
Jisnuson Svasti,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliations Applied Biological Sciences: Environmental Health Program, Chulabhorn Graduate Institute, Bangkok, Thailand, Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand

https://orcid.org/0000-0002-2217-4517

⨯
Voraratt Champattanachai

Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: voraratt@cri.or.th

Affiliations Applied Biological Sciences: Environmental Health Program, Chulabhorn Graduate Institute, Bangkok, Thailand, Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand

https://orcid.org/0000-0002-4287-318X

⨯

Reducing OGT and O-GlcNAcylation enhance the anticancer effects of oxaliplatin in SW620 metastatic colorectal cancer cells

Thirasak Bunsuk,
Juthamard Chantaraamporn,
Photsathorn Mutapat,
Penchatr Diskul Na Ayudthaya,
Daranee Chokchaichamnankit,
Chantragan Srisomsap,
Jisnuson Svasti,
Voraratt Champattanachai

Published: February 10, 2026
https://doi.org/10.1371/journal.pone.0341971

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Cancer treatment
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Colorectal cancer
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