MLND-IU: A multi-stage detection model of subcentimeter lung nodule with improved U-Net++

Huilan Wen; Xiaoqing Luo; Bin Zhong; Yang Xiao; Dengfeng Chen; Lianmin Zhu

doi:10.1371/journal.pone.0341750

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Open Access

Peer-reviewed

Research Article

MLND-IU: A multi-stage detection model of subcentimeter lung nodule with improved U-Net++

Huilan Wen,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Respiratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou City, Jiangxi Province, China
⨯
Xiaoqing Luo,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation School of the First Clinical Medicine, Gannan Medical University, Ganzhou City, Jiangxi Province, China
⨯
Bin Zhong,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Respiratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou City, Jiangxi Province, China
⨯
Yang Xiao,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation School of the First Clinical Medicine, Gannan Medical University, Ganzhou City, Jiangxi Province, China
⨯
Dengfeng Chen,

Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

Affiliation School of the First Clinical Medicine, Gannan Medical University, Ganzhou City, Jiangxi Province, China
⨯
Lianmin Zhu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: 13763928702@163.com

Affiliation Department of Respiratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou City, Jiangxi Province, China

https://orcid.org/0009-0009-7988-5633

⨯

MLND-IU: A multi-stage detection model of subcentimeter lung nodule with improved U-Net++

Huilan Wen,
Xiaoqing Luo,
Bin Zhong,
Yang Xiao,
Dengfeng Chen,
Lianmin Zhu

Published: February 6, 2026
https://doi.org/10.1371/journal.pone.0341750

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