Trends in the burden of gastroesophageal reflux disease in China and Global from 1990 to 2021 and predictive analysis for 2040

Zexu Tang; Zelin Chen; Yongjian Huang; Jinwen Fang; Xiangyang Yang; Chunzhu Li; Huiying Zhang; E. Xie

doi:10.1371/journal.pone.0341619

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Open Access

Peer-reviewed

Research Article

Trends in the burden of gastroesophageal reflux disease in China and Global from 1990 to 2021 and predictive analysis for 2040

Zexu Tang,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliation Graduate School, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China
⨯
Zelin Chen,

Roles Methodology

Affiliation Graduate School, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China
⨯
Yongjian Huang,

Roles Investigation, Software

Current Address: Department of Academic Research, Shantou Hospital of Traditional Chinese Medicine, Shantou, Guangdong, China.

Affiliation Graduate School, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China
⨯
Jinwen Fang,

Roles Data curation

Affiliation Department of the Center for Gastroesophageal Relux Disease, Shantou Hospital of Traditional Chinese Medicine, Shantou, Guangdong, China
⨯
Xiangyang Yang,

Roles Validation

Affiliation Department of the Center for Gastroesophageal Relux Disease, Shantou Hospital of Traditional Chinese Medicine, Shantou, Guangdong, China
⨯
Chunzhu Li,

Roles Supervision

Affiliation Department of the Center for Gastroesophageal Relux Disease, Shantou Hospital of Traditional Chinese Medicine, Shantou, Guangdong, China
⨯
Huiying Zhang ,

Roles Writing – original draft

* E-mail: 1121532184@qq.com (HZ); 1621981300@qq.com (EX)

Affiliation Department of the Center for Gastroesophageal Relux Disease, Shantou Hospital of Traditional Chinese Medicine, Shantou, Guangdong, China
⨯
E. Xie

Roles Conceptualization, Writing – review & editing

* E-mail: 1121532184@qq.com (HZ); 1621981300@qq.com (EX)

Current Address: Department of the Center for Gastroesophageal Relux Disease, Shantou Hospital of Traditional Chinese Medicine, Shantou, Guangdong, China.

Affiliation Department of the Center for Gastroesophageal Relux Disease, Shantou Hospital of Traditional Chinese Medicine, Shantou, Guangdong, China

https://orcid.org/0009-0002-0811-6799

⨯

Trends in the burden of gastroesophageal reflux disease in China and Global from 1990 to 2021 and predictive analysis for 2040

Zexu Tang,
Zelin Chen,
Yongjian Huang,
Jinwen Fang,
Xiangyang Yang,
Chunzhu Li,
Huiying Zhang,
E. Xie

Published: February 2, 2026
https://doi.org/10.1371/journal.pone.0341619

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