Mathematical modeling of the combined effects of thermal burn and local irradiation

Quintessa Hay; Rachel Jennings; Amy Creel; Kyle Gaffney; Christina Wagner; Kidist Maxwell; Rafael Henriquez-Rivera; Ginu Unnikrishnan; Tyler Dant

doi:10.1371/journal.pone.0341595

Loading metrics

Open Access

Peer-reviewed

Research Article

Mathematical modeling of the combined effects of thermal burn and local irradiation

Quintessa Hay,

Roles Conceptualization, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliation Algorithms, Modeling and Assessments Division, Applied Research Associates, Inc., Arlington, Virginia, United States of America
⨯
Rachel Jennings,

Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

Affiliation Takeda Pharmaceuticals, Cambridge, Massachusetts, United States of America

https://orcid.org/0000-0002-4414-7843

⨯
Amy Creel,

Roles Conceptualization, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliation Algorithms, Modeling and Assessments Division, Applied Research Associates, Inc., Arlington, Virginia, United States of America
⨯
Kyle Gaffney,

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliation Algorithms, Modeling and Assessments Division, Applied Research Associates, Inc., Arlington, Virginia, United States of America
⨯
Christina Wagner,

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

Affiliation Rocky Mountain Division, Applied Research Associates, Inc., Littleton, Colorado, United States of America
⨯
Kidist Maxwell,

Roles Conceptualization, Methodology, Visualization, Writing – review & editing

Affiliation Algorithms, Modeling and Assessments Division, Applied Research Associates, Inc., Arlington, Virginia, United States of America
⨯
Rafael Henriquez-Rivera,

Roles Writing – review & editing

Affiliation Software Enterprise Division; Applied Research Associates, Inc., Raleigh, North Carolina, United States of America
⨯
Ginu Unnikrishnan,

Roles Project administration, Writing – review & editing

Affiliation Algorithms, Modeling and Assessments Division, Applied Research Associates, Inc., Arlington, Virginia, United States of America
⨯
Tyler Dant

Roles Funding acquisition, Project administration, Writing – review & editing

* E-mail: tdant@ara.com

Affiliation Algorithms, Modeling and Assessments Division, Applied Research Associates, Inc., Arlington, Virginia, United States of America

https://orcid.org/0009-0005-6433-9518

⨯

Mathematical modeling of the combined effects of thermal burn and local irradiation

Quintessa Hay,
Rachel Jennings,
Amy Creel,
Kyle Gaffney,
Christina Wagner,
Kidist Maxwell,
Rafael Henriquez-Rivera,
Ginu Unnikrishnan,
Tyler Dant

Published: February 10, 2026
https://doi.org/10.1371/journal.pone.0341595

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Burns
Is the Subject Area "Burns" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Ionizing radiation
Is the Subject Area "Ionizing radiation" applicable to this article?

Thanks for your feedback.
Immune cells
Is the Subject Area "Immune cells" applicable to this article?

Thanks for your feedback.
Lymphocytes
Is the Subject Area "Lymphocytes" applicable to this article?

Thanks for your feedback.
Wound healing
Is the Subject Area "Wound healing" applicable to this article?

Thanks for your feedback.