The ketogenic diet alleviates autoimmune thyroiditis caused by Th17/Treg imbalance by inhibiting the HMGB1/NLRP3 signaling pathway

Yue Luo; Hao Gao; Mengzhen Wang; Zhimin Wang; Zhe Jin; Nan Song; Ziyu Liu; Xiao Yang

doi:10.1371/journal.pone.0341564

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Open Access

Peer-reviewed

Research Article

The ketogenic diet alleviates autoimmune thyroiditis caused by Th17/Treg imbalance by inhibiting the HMGB1/NLRP3 signaling pathway

Yue Luo ,

Contributed equally to this work with: Yue Luo, Hao Gao, Mengzhen Wang

Roles Formal analysis, Writing – original draft, Data curation

Affiliation School of Graduate Studies at Liaoning University of Traditional Chinese Medicine, Shenyang, China
⨯
Hao Gao ,

Contributed equally to this work with: Yue Luo, Hao Gao, Mengzhen Wang

Roles Data curation, Formal analysis, Writing – original draft

Affiliation School of Graduate Studies at Liaoning University of Traditional Chinese Medicine, Shenyang, China

https://orcid.org/0009-0002-1036-5532

⨯
Mengzhen Wang ,

Contributed equally to this work with: Yue Luo, Hao Gao, Mengzhen Wang

Roles Data curation, Formal analysis, Writing – original draft

Affiliation School of Graduate Studies at Liaoning University of Traditional Chinese Medicine, Shenyang, China
⨯
Zhimin Wang,

Roles Conceptualization

Affiliation Department of the First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, China
⨯
Zhe Jin,

Roles Methodology

Affiliation Department of the Second Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, China
⨯
Nan Song ,

Roles Project administration

* E-mail: cpcool@126.com (NS), 894458722@qq.com (ZL), dfziran2023@163.com (XY)

Affiliation Department of Medical Laboratory, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
⨯
Ziyu Liu ,

Roles Investigation, Project administration

* E-mail: cpcool@126.com (NS), 894458722@qq.com (ZL), dfziran2023@163.com (XY)

Affiliation Department of Liaoning Institute of Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, China
⨯
Xiao Yang

Roles Funding acquisition, Resources, Supervision

* E-mail: cpcool@126.com (NS), 894458722@qq.com (ZL), dfziran2023@163.com (XY)

Affiliation Department of Liaoning Institute of Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, China

https://orcid.org/0009-0009-5546-472X

⨯

The ketogenic diet alleviates autoimmune thyroiditis caused by Th17/Treg imbalance by inhibiting the HMGB1/NLRP3 signaling pathway

Yue Luo,
Hao Gao,
Mengzhen Wang,
Zhimin Wang,
Zhe Jin,
Nan Song,
Ziyu Liu,
Xiao Yang

Published: May 8, 2026
https://doi.org/10.1371/journal.pone.0341564

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