Uralenol, Glycyrol, and Abyssinone II as potent inhibitors of fibroblast growth factor receptor 2 from anti-cancer plants: A deep learning and molecular dynamics approach

Alomgir Hossain; Md. Sanowar Hossan; Md. Shahanur Prodhan; Md. Nahid Hasan Joy; Muntasir Rahman Siam; Md. Ekhtiar Rahman; Mohammad Nurul Matin

doi:10.1371/journal.pone.0341498

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Open Access

Peer-reviewed

Research Article

Uralenol, Glycyrol, and Abyssinone II as potent inhibitors of fibroblast growth factor receptor 2 from anti-cancer plants: A deep learning and molecular dynamics approach

Alomgir Hossain ,

Roles Conceptualization, Data curation, Formal analysis, Software, Writing – original draft

* E-mail: nmatin@ru.ac.bd (MNM); alamgir199817@gmail.com (AH)

Affiliations Computational Biosciences and Chemistry Research Organization, Rajshahi, Bangladesh, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, Bangladesh

https://orcid.org/0000-0002-7966-7240

⨯
Md. Sanowar Hossan,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Computational Biosciences and Chemistry Research Organization, Rajshahi, Bangladesh
⨯
Md. Shahanur Prodhan,

Roles Formal analysis, Software, Writing – review & editing

Affiliation Computational Biosciences and Chemistry Research Organization, Rajshahi, Bangladesh
⨯
Md. Nahid Hasan Joy,

Roles Formal analysis, Software, Writing – review & editing

Affiliation Computational Biosciences and Chemistry Research Organization, Rajshahi, Bangladesh

https://orcid.org/0009-0009-9322-2828

⨯
Muntasir Rahman Siam,

Roles Data curation, Writing – review & editing

Affiliation Computational Biosciences and Chemistry Research Organization, Rajshahi, Bangladesh
⨯
Md. Ekhtiar Rahman,

Roles Data curation, Methodology, Software, Writing – review & editing

Affiliations Computational Biosciences and Chemistry Research Organization, Rajshahi, Bangladesh, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, Bangladesh
⨯
Mohammad Nurul Matin

Roles Conceptualization, Funding acquisition, Supervision

* E-mail: nmatin@ru.ac.bd (MNM); alamgir199817@gmail.com (AH)

Affiliations Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, Bangladesh, Department of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea

https://orcid.org/0000-0002-3594-2570

⨯

Uralenol, Glycyrol, and Abyssinone II as potent inhibitors of fibroblast growth factor receptor 2 from anti-cancer plants: A deep learning and molecular dynamics approach

Alomgir Hossain,
Md. Sanowar Hossan,
Md. Shahanur Prodhan,
Md. Nahid Hasan Joy,
Muntasir Rahman Siam,
Md. Ekhtiar Rahman,
Mohammad Nurul Matin

Published: January 30, 2026
https://doi.org/10.1371/journal.pone.0341498

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