Pathogenic KRAS variants disrupt structure and dynamics: Insights from integrated computational analyses

• Saqib Ishaq ,

  Contributed equally to this work with: Saqib Ishaq, Aizaz Ali

  Roles Conceptualization, Data curation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: yasirali@awkum.edu.pk (YA); saqib.ishaq@kkkuk.edu.pk (SI); aminbiotech7@gmail.com (AU)

  Affiliations Guangdong Provincial Key Laboratory of System Biology and Synthetics Biology for Urogenital Tumors, School of Basic Medicine, Shenzhen University Medical School, Shenzhen University (SZU), Shenzhen, Guangdong, China, Department of Computer Sciences and Bioinformatics, Khushal Khan Khattak University Karak, Karak, Pakistan, Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, Pakistan

  https://orcid.org/0009-0000-8726-1681

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• Aizaz Ali ,

  Contributed equally to this work with: Saqib Ishaq, Aizaz Ali

  Roles Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biotechnology, Abdul Wali Khan University Mardan, Mardan, KPK, Pakistan

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• Obaid Habib,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Guangdong Provincial Key Laboratory of System Biology and Synthetics Biology for Urogenital Tumors, School of Basic Medicine, Shenzhen University Medical School, Shenzhen University (SZU), Shenzhen, Guangdong, China

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• Shabir Ahmad Usmani,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Department of Computer Sciences and Bioinformatics, Khushal Khan Khattak University Karak, Karak, Pakistan

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• Irshad Ur Rehman,

  Roles Supervision

  Affiliation Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, Pakistan

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• Abdul Aziz,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Computer Sciences and Bioinformatics, Khushal Khan Khattak University Karak, Karak, Pakistan

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• Yasir Ali ,

  Roles Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: yasirali@awkum.edu.pk (YA); saqib.ishaq@kkkuk.edu.pk (SI); aminbiotech7@gmail.com (AU)

  Affiliations Department of Biotechnology, Abdul Wali Khan University Mardan, Mardan, KPK, Pakistan, School of Medicine, the Chinese University of Hong Kong, Shenzhen, China

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• Ajaz Ahmad,

  Roles Supervision

  Affiliation Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

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• Amin Ullah

  Roles Supervision, Writing – review & editing

  * E-mail: yasirali@awkum.edu.pk (YA); saqib.ishaq@kkkuk.edu.pk (SI); aminbiotech7@gmail.com (AU)

  Affiliation Department of Allied Health Sciences, Molecular Biology Laboratory, Iqra National University (INU) Peshawar, Peshawar, Pakistan

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