Intratumoral spatial heterogeneity at non-contrast CT predicts histological grading of invasive pulmonary adenocarcinoma: a multicenter retrospective study

Shize Qin; Sijia Zhou; Yongying Liu; Dan Su; Qing Jia; Yang Li; Guohong Shen; Xiufu Zhang

doi:10.1371/journal.pone.0341163

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Open Access

Peer-reviewed

Research Article

Intratumoral spatial heterogeneity at non-contrast CT predicts histological grading of invasive pulmonary adenocarcinoma: a multicenter retrospective study

Shize Qin ,

Contributed equally to this work with: Shize Qin, Sijia Zhou, Yongying Liu

Roles Conceptualization, Data curation, Methodology, Project administration, Writing – original draft

Affiliation Department of Radiology, Jiangjin Central Hospital of Chongqing, Jiangzhou Avenue, Dingshan Sub-district, Jiangjin District, Chongqing, China
⨯
Sijia Zhou ,

Contributed equally to this work with: Shize Qin, Sijia Zhou, Yongying Liu

Roles Methodology, Software, Writing – original draft

Affiliation Department of Radiology, Jiangjin Central Hospital of Chongqing, Jiangzhou Avenue, Dingshan Sub-district, Jiangjin District, Chongqing, China
⨯
Yongying Liu ,

Contributed equally to this work with: Shize Qin, Sijia Zhou, Yongying Liu

Roles Data curation, Investigation

Affiliation Department of Radiology, Jiangjin Central Hospital of Chongqing, Jiangzhou Avenue, Dingshan Sub-district, Jiangjin District, Chongqing, China
⨯
Dan Su,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Radiology, Jiangjin Central Hospital of Chongqing, Jiangzhou Avenue, Dingshan Sub-district, Jiangjin District, Chongqing, China
⨯
Qing Jia,

Roles Investigation, Methodology

Affiliation Department of Radiology, Chongqing General Hospital, Xingguang Avenue, Liangjiang New Area, Chongqing, China
⨯
Yang Li,

Roles Methodology, Writing – review & editing

Affiliation Department of Research and Development, Shanghai United Imaging Intelligence Co., Ltd., Yunjin Road, Xuhui District, Shanghai, China
⨯
Guohong Shen ,

Roles Investigation, Methodology

¶‡ These authors contributed equally as corresponding authors.

Affiliation Department of Radiology, People’s Hospital of Chongqing Hechuan, Hechuan District, Chongqing, China
⨯
Xiufu Zhang

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: xray1895@163.com

¶‡ These authors contributed equally as corresponding authors.

Affiliation Department of Radiology, Jiangjin Central Hospital of Chongqing, Jiangzhou Avenue, Dingshan Sub-district, Jiangjin District, Chongqing, China

https://orcid.org/0009-0001-3357-4495

⨯

Intratumoral spatial heterogeneity at non-contrast CT predicts histological grading of invasive pulmonary adenocarcinoma: a multicenter retrospective study

Shize Qin,
Sijia Zhou,
Yongying Liu,
Dan Su,
Qing Jia,
Yang Li,
Guohong Shen,
Xiufu Zhang

Published: February 2, 2026
https://doi.org/10.1371/journal.pone.0341163

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