A cost-effectiveness analysis comparing pembrolizumab combined with chemotherapy versus chemotherapy alone for advanced biliary tract cancer: US and China perspectives

Chunhua Zhang; Hua Liang; Yanni Qin; Xiaolan Tan; Xiaoqing Su; Xin Tian; Yumei Nong

doi:10.1371/journal.pone.0341154

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Open Access

Peer-reviewed

Research Article

A cost-effectiveness analysis comparing pembrolizumab combined with chemotherapy versus chemotherapy alone for advanced biliary tract cancer: US and China perspectives

Chunhua Zhang ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Software, Validation, Writing – original draft

* E-mail: zhangchunhua886@outlook.com (CZ); 236706777@qq.com (YN)

¶☯ These authors contributed equally to this work.

Affiliation Department of Pharmacy, The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People’s Republic of China

https://orcid.org/0009-0009-5729-7670

⨯
Hua Liang ,

Contributed equally to this work with: Hua Liang

Roles Conceptualization, Data curation, Formal analysis, Project administration, Validation, Writing – original draft

¶☯ These authors contributed equally to this work.

Affiliation Department of Pharmacy, Baise People’s Hospital, Baise, Guangxi, People’s Republic of China
⨯
Yanni Qin,

Roles Data curation, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft

Affiliation Department of Pharmacy, The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People’s Republic of China
⨯
Xiaolan Tan,

Roles Data curation, Formal analysis, Investigation, Resources, Validation, Visualization, Writing – review & editing

Affiliation Department of Pharmacy, The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People’s Republic of China
⨯
Xiaoqing Su,

Roles Data curation, Investigation, Resources, Validation, Visualization, Writing – review & editing

Affiliation Department of Pharmacy, The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People’s Republic of China
⨯
Xin Tian,

Roles Data curation, Validation, Writing – original draft

Affiliation Department of Pharmacy, The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People’s Republic of China
⨯
Yumei Nong

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: zhangchunhua886@outlook.com (CZ); 236706777@qq.com (YN)

Affiliation Department of Pharmacy, The People’s Hospital of Chongzuo, Chongzuo, Guangxi, People’s Republic of China
⨯

A cost-effectiveness analysis comparing pembrolizumab combined with chemotherapy versus chemotherapy alone for advanced biliary tract cancer: US and China perspectives

Chunhua Zhang,
Hua Liang,
Yanni Qin,
Xiaolan Tan,
Xiaoqing Su,
Xin Tian,
Yumei Nong

Published: January 22, 2026
https://doi.org/10.1371/journal.pone.0341154

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Chemotherapy
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