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Omics-aided design genome editing strategy for challenging human immortalized cell models
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Patricia Mendoza-Garcia,
Roles Conceptualization, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing
Affiliation Assays, Profiling & Cell Sciences, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
⨯ - Benjamin Keith,
- Markus Nordberg,
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Ella Quist,
Roles Investigation
Affiliation Assays, Profiling & Cell Sciences, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
⨯ - Cristina Ferrás,
- Ghaith M. Hamza,
- Ramy Elgendy,
- Stephanie Kay Ashenden,
- Jordi Chi,
- Natalie R. van Zuydam,
- Neil Hattersley,
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Xiang Zhang
Roles Conceptualization, Formal analysis, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing
* E-mail: xiang.zhang6@astrazeneca.com
Affiliation Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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https://orcid.org/0000-0002-6084-7962
Omics-aided design genome editing strategy for challenging human immortalized cell models
- Patricia Mendoza-Garcia,
- Benjamin Keith,
- Markus Nordberg,
- Ella Quist,
- Cristina Ferrás,
- Ghaith M. Hamza,
- Ramy Elgendy,
- Stephanie Kay Ashenden,
- Jordi Chi,
- Natalie R. van Zuydam
- Published: February 12, 2026
- https://doi.org/10.1371/journal.pone.0341124