Identification and characterization of tryptophan metabolism-related genes in carotid artery plaques

Xiaodong Jia; Zhen Wang; Lin Bai; Jianmei Wei; Xizi Wang; Zhaona Song; Xianchao Guo; Runze Jiang; Qiang Zhang

doi:10.1371/journal.pone.0341122

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Open Access

Peer-reviewed

Research Article

Identification and characterization of tryptophan metabolism-related genes in carotid artery plaques

Xiaodong Jia ,

Contributed equally to this work with: Xiaodong Jia, Zhen Wang, Lin Bai

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Joint Laboratory for Translational Medicine Research, Liaocheng People’s Hospital, Liaocheng, Shandong, China
⨯
Zhen Wang ,

Contributed equally to this work with: Xiaodong Jia, Zhen Wang, Lin Bai

Roles Investigation, Methodology, Writing – review & editing

Affiliation Neck- Shoulder and Lumbocrural Pain Hospital, Shandong First Medical University, Jinan, Shandong, China

https://orcid.org/0009-0004-9976-7144

⨯
Lin Bai ,

Contributed equally to this work with: Xiaodong Jia, Zhen Wang, Lin Bai

Roles Formal analysis, Methodology, Software, Visualization, Writing – original draft

Affiliation Traditional Chinese Medicine Innovation Research Institute, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Jianmei Wei,

Roles Investigation, Validation, Visualization

Affiliation Joint Laboratory for Translational Medicine Research, Liaocheng People’s Hospital, Liaocheng, Shandong, China
⨯
Xizi Wang,

Roles Software, Validation, Visualization

Affiliation Joint Laboratory for Translational Medicine Research, Liaocheng People’s Hospital, Liaocheng, Shandong, China
⨯
Zhaona Song,

Roles Software, Validation, Visualization

Affiliation Joint Laboratory for Translational Medicine Research, Liaocheng People’s Hospital, Liaocheng, Shandong, China
⨯
Xianchao Guo,

Roles Formal analysis, Methodology, Software

Affiliation Traditional Chinese Medicine Innovation Research Institute, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Runze Jiang ,

Roles Conceptualization, Methodology, Writing – review & editing

* E-mail: qiangzhang72@126.com; solon.jiang@gmail.com

Affiliation Traditional Chinese Medicine Innovation Research Institute, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
⨯
Qiang Zhang

Roles Conceptualization, Data curation, Methodology, Writing – review & editing

* E-mail: qiangzhang72@126.com; solon.jiang@gmail.com

Affiliation Joint Laboratory for Translational Medicine Research, Liaocheng People’s Hospital, Liaocheng, Shandong, China

https://orcid.org/0000-0002-7666-2188

⨯

Identification and characterization of tryptophan metabolism-related genes in carotid artery plaques

Xiaodong Jia,
Zhen Wang,
Lin Bai,
Jianmei Wei,
Xizi Wang,
Zhaona Song,
Xianchao Guo,
Runze Jiang,
Qiang Zhang

Published: February 2, 2026
https://doi.org/10.1371/journal.pone.0341122

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Tryptophan
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Atherosclerosis
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Amino acid metabolism
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Metabolic pathways
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Carotid arteries
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Serotonin
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Gene expression
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Immune cells
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