Effect of esketamine-based patient-controlled intravenous analgesia on postoperative pain and quality of recovery after video-assisted thoracoscopic lobectomy: A prospective, double-blind, randomized controlled trial

Ruirui Bi; Jiqiang Zhang; Ruijuan Liu; Lijuan Li; Yuxi Su; Mengjun Xu; Wenjun Yan

doi:10.1371/journal.pone.0340864

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Open Access

Peer-reviewed

Research Article

Effect of esketamine-based patient-controlled intravenous analgesia on postoperative pain and quality of recovery after video-assisted thoracoscopic lobectomy: A prospective, double-blind, randomized controlled trial

Ruirui Bi,

Roles Conceptualization, Data curation, Writing – original draft

Affiliation Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province, China
⨯
Jiqiang Zhang,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Lanzhou, Gansu Province, China
⨯
Ruijuan Liu,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Anesthesiology, Gansu Provincial Hospital, Lanzhou, Gansu Province, China
⨯
Lijuan Li,

Roles Data curation, Validation, Writing – review & editing

Affiliation The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Lanzhou, Gansu Province, China
⨯
Yuxi Su,

Roles Data curation, Validation, Writing – review & editing

Affiliation The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Lanzhou, Gansu Province, China
⨯
Mengjun Xu,

Roles Data curation, Validation, Writing – review & editing

Affiliation Department of Anesthesiology, Gansu Provincial Hospital, Lanzhou, Gansu Province, China
⨯
Wenjun Yan

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: 13893370700@163.com

Affiliation Department of Anesthesiology, Gansu Provincial Hospital, Lanzhou, Gansu Province, China

https://orcid.org/0009-0005-1811-2304

⨯

Effect of esketamine-based patient-controlled intravenous analgesia on postoperative pain and quality of recovery after video-assisted thoracoscopic lobectomy: A prospective, double-blind, randomized controlled trial

Ruirui Bi,
Jiqiang Zhang,
Ruijuan Liu,
Lijuan Li,
Yuxi Su,
Mengjun Xu,
Wenjun Yan

Published: January 27, 2026
https://doi.org/10.1371/journal.pone.0340864

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Pain
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Analgesia
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Depression
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Lobectomy
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Surgical and invasive medical procedures
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