The additive effect of IgE-mediated and pseudoallergic hypersensitivity in RBL-2H3 cells and guinea pigs

Yu Zhang; Qilong Xu; Chengbo Zheng; Cunyu Li; Yunfeng Zheng; Guoping Peng

doi:10.1371/journal.pone.0340855

Loading metrics

Open Access

Peer-reviewed

Research Article

The additive effect of IgE-mediated and pseudoallergic hypersensitivity in RBL-2H3 cells and guinea pigs

Yu Zhang,

Roles Data curation, Formal analysis, Writing – original draft

Affiliations Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China, National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing, Jiangsu, China
⨯
Qilong Xu,

Roles Investigation, Writing – review & editing

Affiliations School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China, National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing, Jiangsu, China
⨯
Chengbo Zheng,

Roles Visualization, Writing – review & editing

Affiliations School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China, National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing, Jiangsu, China
⨯
Cunyu Li,

Roles Resources, Software, Writing – review & editing

Affiliations School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China, National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing, Jiangsu, China
⨯
Yunfeng Zheng,

Roles Supervision, Writing – review & editing

Affiliations School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China, National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing, Jiangsu, China
⨯
Guoping Peng

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Writing – review & editing

* E-mail: PGP@njucm.edu.cn

Affiliations School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China, National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing, Jiangsu, China

https://orcid.org/0009-0004-3731-246X

⨯

The additive effect of IgE-mediated and pseudoallergic hypersensitivity in RBL-2H3 cells and guinea pigs

Yu Zhang,
Qilong Xu,
Chengbo Zheng,
Cunyu Li,
Yunfeng Zheng,
Guoping Peng

Published: February 5, 2026
https://doi.org/10.1371/journal.pone.0340855

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hypersensitivity
Is the Subject Area "Hypersensitivity" applicable to this article?

Thanks for your feedback.
Guinea pigs
Is the Subject Area "Guinea pigs" applicable to this article?

Thanks for your feedback.
Histamine
Is the Subject Area "Histamine" applicable to this article?

Thanks for your feedback.
Allergies
Is the Subject Area "Allergies" applicable to this article?

Thanks for your feedback.
Drug therapy
Is the Subject Area "Drug therapy" applicable to this article?

Thanks for your feedback.
Histamine release
Is the Subject Area "Histamine release" applicable to this article?

Thanks for your feedback.
Blood plasma
Is the Subject Area "Blood plasma" applicable to this article?

Thanks for your feedback.
Vancomycin
Is the Subject Area "Vancomycin" applicable to this article?

Thanks for your feedback.