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Open Access
Peer-reviewed
Research Article
Methylation-specific, universal, and highly sensitive identification of ctDNA in prostate cancer by multiplex droplet digital PCR
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Søren Kahns ,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing
* E-mail: soren.kahns@rsyd.dk
Affiliation Department of Biochemistry and Immunology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark
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Ahmed H. Zedan,
Roles Conceptualization, Data curation, Funding acquisition, Validation, Writing – review & editing
Affiliation Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark
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Mads M. Aagaard,
Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing
Affiliation Department of Genetics, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark
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Luisa M. D. Canto,
Roles Investigation, Validation, Writing – review & editing
Affiliations Department of Biochemistry and Immunology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark, Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark
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Sanne Kjær-Frifeldt,
Roles Investigation, Validation, Writing – review & editing
Affiliation Department of Pathology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark
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Stine V. Eriksen,
Roles Investigation, Validation, Writing – review & editing
Affiliation Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark
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Christine V. Madsen,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliation Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark
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Jonna S. Madsen,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliations Department of Biochemistry and Immunology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark, Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Palle J. S. Osther,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliations Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark, Department of Urology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark
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Torben F. Hansen,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliations Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark, Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Rikke F. Andersen
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing
Affiliations Department of Biochemistry and Immunology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark, Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark
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Methylation-specific, universal, and highly sensitive identification of ctDNA in prostate cancer by multiplex droplet digital PCR
- Søren Kahns,
- Ahmed H. Zedan,
- Mads M. Aagaard,
- Luisa M. D. Canto,
- Sanne Kjær-Frifeldt,
- Stine V. Eriksen,
- Christine V. Madsen,
- Jonna S. Madsen,
- Palle J. S. Osther,
- Torben F. Hansen
- Published: January 29, 2026
- https://doi.org/10.1371/journal.pone.0340786