Integrative metagenomics and structural bioinformatics identify explainable gut microbial variants associated with Crohn’s disease

Nadeem Khan; Muhammad Muneeb Nasir; Ubair Aziz; Haseeb Manzoor; Muhammad Faheem Raziq; Zamir Hussain; Ishrat Jabeen; Masood Ur Rehman Kayani

doi:10.1371/journal.pone.0340748

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Open Access

Peer-reviewed

Research Article

Integrative metagenomics and structural bioinformatics identify explainable gut microbial variants associated with Crohn’s disease

Nadeem Khan,

Roles Formal analysis

Affiliation School of Interdisciplinary Engineering & Sciences (SINES), National University of Sciences & Technology (NUST), Sector H-12, Islamabad, Pakistan
⨯
Muhammad Muneeb Nasir,

Roles Formal analysis

Affiliation School of Interdisciplinary Engineering & Sciences (SINES), National University of Sciences & Technology (NUST), Sector H-12, Islamabad, Pakistan

https://orcid.org/0009-0004-8894-3747

⨯
Ubair Aziz,

Roles Formal analysis

Affiliation School of Interdisciplinary Engineering & Sciences (SINES), National University of Sciences & Technology (NUST), Sector H-12, Islamabad, Pakistan
⨯
Haseeb Manzoor,

Roles Formal analysis

Affiliation School of Interdisciplinary Engineering & Sciences (SINES), National University of Sciences & Technology (NUST), Sector H-12, Islamabad, Pakistan
⨯
Muhammad Faheem Raziq,

Roles Formal analysis

Affiliation School of Interdisciplinary Engineering & Sciences (SINES), National University of Sciences & Technology (NUST), Sector H-12, Islamabad, Pakistan
⨯
Zamir Hussain,

Roles Methodology

Affiliation School of Interdisciplinary Engineering & Sciences (SINES), National University of Sciences & Technology (NUST), Sector H-12, Islamabad, Pakistan
⨯
Ishrat Jabeen,

Roles Methodology

Affiliation School of Interdisciplinary Engineering & Sciences (SINES), National University of Sciences & Technology (NUST), Sector H-12, Islamabad, Pakistan
⨯
Masood Ur Rehman Kayani

Roles Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: masood.kayani@ymail.com

Affiliation School of Interdisciplinary Engineering & Sciences (SINES), National University of Sciences & Technology (NUST), Sector H-12, Islamabad, Pakistan

https://orcid.org/0000-0002-7425-1756

⨯

Integrative metagenomics and structural bioinformatics identify explainable gut microbial variants associated with Crohn’s disease

Nadeem Khan,
Muhammad Muneeb Nasir,
Ubair Aziz,
Haseeb Manzoor,
Muhammad Faheem Raziq,
Zamir Hussain,
Ishrat Jabeen,
Masood Ur Rehman Kayani

Published: July 10, 2026
https://doi.org/10.1371/journal.pone.0340748

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