Persistent foot-and-mouth disease virus infection of the bovine nasopharynx is associated with suppression of innate and cellular immunity

Benedikt Litz; Florian Pfaff; Leonie F. Forth; Sara Hägglund; Jean-François Valarcher; Martin Beer; Michael Eschbaumer

doi:10.1371/journal.pone.0340425

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Open Access

Peer-reviewed

Research Article

Persistent foot-and-mouth disease virus infection of the bovine nasopharynx is associated with suppression of innate and cellular immunity

Benedikt Litz,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

https://orcid.org/0000-0003-2263-7048

⨯
Florian Pfaff,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Visualization, Writing – review & editing

Affiliation Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

https://orcid.org/0000-0003-0178-6183

⨯
Leonie F. Forth,

Roles Investigation

Current address: Department of Biological Safety, German Federal Institute for Risk Assessment, Berlin, Germany.

Affiliation Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
⨯
Sara Hägglund,

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Host Pathogen Interaction Group, Unit of Ruminant Medicine, Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

https://orcid.org/0000-0002-6983-5722

⨯
Jean-François Valarcher,

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Host Pathogen Interaction Group, Unit of Ruminant Medicine, Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

https://orcid.org/0000-0002-8564-5603

⨯
Martin Beer,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
⨯
Michael Eschbaumer

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: Michael.Eschbaumer@fli.de

Affiliation Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

https://orcid.org/0000-0002-1104-0695

⨯

Persistent foot-and-mouth disease virus infection of the bovine nasopharynx is associated with suppression of innate and cellular immunity

Benedikt Litz,
Florian Pfaff,
Leonie F. Forth,
Sara Hägglund,
Jean-François Valarcher,
Martin Beer,
Michael Eschbaumer

Published: January 23, 2026
https://doi.org/10.1371/journal.pone.0340425

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Viral gene expression
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Viral persistence and latency
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Immune response
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T cells
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Cattle
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Transcriptome analysis
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