Establishment and investigation of a surgical model of hypothyroidism in Wistar rats

Yue Wang; Jiayu Zhu; Fang Yu; Han Gao; Yuanyuan Fu; Chunyu Chu; Chao Yu; Zhonghui Li; Xiao Liu; Meng Wang; Yuan Liu; Luming Zheng; Qingqing He

doi:10.1371/journal.pone.0340302

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Open Access

Peer-reviewed

Research Article

Establishment and investigation of a surgical model of hypothyroidism in Wistar rats

Yue Wang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft, Writing – review & editing

Affiliations First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China, Department of Thyroid and Breast Surgery, The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China
⨯
Jiayu Zhu,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China
⨯
Fang Yu,

Roles Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft

Affiliation Department of Thyroid and Breast Surgery, The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China
⨯
Han Gao,

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Chinese Medicine College, Shandong University of Traditional Chinese Medicine, Jinan, China
⨯
Yuanyuan Fu,

Roles Data curation, Formal analysis, Software, Writing – original draft, Writing – review & editing

Affiliation School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Chunyu Chu,

Roles Conceptualization, Data curation, Formal analysis, Software

Affiliations Clinical Medicine College, Shandong Second Medical University, Weifang, China, Department of Obstetrics and Gynecology, The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China
⨯
Chao Yu,

Roles Methodology, Software, Validation, Visualization

Affiliation Basic Medical Laboratory, The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China
⨯
Zhonghui Li,

Roles Formal analysis, Resources, Visualization, Writing – original draft

Affiliations First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China, Department of Thyroid and Breast Surgery, The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China
⨯
Xiao Liu,

Roles Methodology, Software, Supervision

Affiliation Basic Medical Laboratory, The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China
⨯
Meng Wang,

Roles Investigation, Supervision, Writing – review & editing

Affiliation Department of Thyroid and Breast Surgery, The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China
⨯
Yuan Liu,

Roles Conceptualization, Resources, Software, Writing – review & editing

Affiliation Department of Thyroid and Breast Surgery, The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China
⨯
Luming Zheng,

Roles Methodology, Software, Supervision, Writing – review & editing

Affiliation Department of Thyroid and Breast Surgery, The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China
⨯
Qingqing He

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: heqingqing@yeah.net

Affiliation Department of Thyroid and Breast Surgery, The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China

https://orcid.org/0000-0002-2159-1976

⨯

Establishment and investigation of a surgical model of hypothyroidism in Wistar rats

Yue Wang,
Jiayu Zhu,
Fang Yu,
Han Gao,
Yuanyuan Fu,
Chunyu Chu,
Chao Yu,
Zhonghui Li,
Xiao Liu,
Meng Wang

Published: January 20, 2026
https://doi.org/10.1371/journal.pone.0340302

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Thyroid
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Hypothyroidism
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Surgical and invasive medical procedures
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Thyroidectomy
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Thyroid-stimulating hormone
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Blood
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Endocrine system procedures
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