Targeting ceramide metabolism to restore hypoxia-induced apoptosis in p53-deficient colon cancer cells

• Karen Mechleb ,

  Contributed equally to this work with: Karen Mechleb, Nancy Hourani

  Roles Investigation, Methodology

  Affiliations Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon, Department of Louvain, Institute of Biomolecular Science and Technology, Faculty of Sciences, Catholic University of Louvain, Louvain, Belgium

  ⨯
• Nancy Hourani ,

  Contributed equally to this work with: Karen Mechleb, Nancy Hourani

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon, Department of Pediatrics and Adolescent Medicine, Center for Infectious Diseases Research, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

  https://orcid.org/0000-0002-0597-0044

  ⨯
• Maya Fakhry,

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

  https://orcid.org/0000-0002-1274-9348

  ⨯
• Osama A. Alyamani,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Toxicology, Toxicology Lab Research and Training Center, Faculty of Health Sciences, American University of Science & Technology (AUST), Beirut, Lebanon, Forensic Toxicology Laboratory, Center of Forensic & Digital Sciences, Abu Dhabi Judicial Department (ADJD), United Arab Emirates

  ⨯
• Rouba Hage-Sleiman,

  Roles Writing – review & editing

  Affiliation Department of Biology, Faculty of Sciences, Lebanese University, Hadath, Lebanon

  ⨯
• Hicham Younes,

  Roles Investigation, Methodology

  Affiliations Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon, Department of Biology, Faculty of Sciences, Lebanese University, Hadath, Lebanon

  ⨯
• Antoine Abou Fayad,

  Roles Investigation, Methodology

  Affiliation Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

  ⨯
• Nadia Soudani,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United States of America

  ⨯
• Amer Sakr,

  Roles Investigation, Methodology

  Affiliation Department of Toxicology, Toxicology Lab Research and Training Center, Faculty of Health Sciences, American University of Science & Technology (AUST), Beirut, Lebanon

  ⨯
• Nadine Darwiche,

  Roles Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

  https://orcid.org/0000-0002-1862-5426

  ⨯
• Georges Nemer,

  Roles Writing – review & editing

  Affiliation Division of Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar

  https://orcid.org/0000-0003-2157-5279

  ⨯
• Raya Saab,

  Roles Writing – review & editing

  Affiliation Department of Pediatrics, Division of Hematology/Oncology, Stanford University, Stanford, California, United States of America

  https://orcid.org/0000-0001-5776-2303

  ⨯
• Marguerite Mrad ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mrad@wustl.edu (MM); gdbaibo@aub.edu.lb (GD)

  Affiliations Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon, Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

  ⨯
• Ghassan Dbaibo

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: mrad@wustl.edu (MM); gdbaibo@aub.edu.lb (GD)

  Affiliations Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon, Department of Pediatrics and Adolescent Medicine, Center for Infectious Diseases Research, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

  ⨯