Myeloid Fmr1 deficiency in mice results in reduced serum cholesterol and altered bile pathway gene expression

Xiaoning Zhao; Jianchang Zhou; Kuang-Yuh Chyu; Ebru Erbay; Bojan Cercek; Prediman K. Shah; Paul C. Dimayuga

doi:10.1371/journal.pone.0340222

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Open Access

Peer-reviewed

Research Article

Myeloid Fmr1 deficiency in mice results in reduced serum cholesterol and altered bile pathway gene expression

Xiaoning Zhao,

Roles Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Atherosclerosis Research Center, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Jianchang Zhou,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Atherosclerosis Research Center, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Kuang-Yuh Chyu,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Atherosclerosis Research Center, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Ebru Erbay,

Roles Conceptualization, Writing – review & editing

Affiliation Division of Cardiology, David Geffen School of Medicine, UCLA, Los Angeles, California, United States of America
⨯
Bojan Cercek,

Roles Formal analysis, Resources, Writing – review & editing

Affiliation Atherosclerosis Research Center, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Prediman K. Shah,

Roles Formal analysis, Supervision, Writing – review & editing

Affiliation Atherosclerosis Research Center, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Paul C. Dimayuga

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: Paul.dimayuga@cshs.org

Affiliation Atherosclerosis Research Center, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

https://orcid.org/0000-0003-1196-1926

⨯

Myeloid Fmr1 deficiency in mice results in reduced serum cholesterol and altered bile pathway gene expression

Xiaoning Zhao,
Jianchang Zhou,
Kuang-Yuh Chyu,
Ebru Erbay,
Bojan Cercek,
Prediman K. Shah,
Paul C. Dimayuga

Published: January 12, 2026
https://doi.org/10.1371/journal.pone.0340222

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Bile
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Cholesterol
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Gene expression
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Diet
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Chemical synthesis
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Bone marrow cells
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Macrophages
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Metabolic pathways
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