Exploring the toxicological mechanisms of Benzo[a]anthracene (BaA) exposure in lung adenocarcinoma (LUAD) via network toxicology, machine learning, and multi-dimensional bioinformatics analysis

Zhiyao Shi; Zhiyong Fang; Qiang Qin; Yu Gao; Xi Yang; Likun Liu; Xixing Wang

doi:10.1371/journal.pone.0340116

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Peer-reviewed

Research Article

Exploring the toxicological mechanisms of Benzo[a]anthracene (BaA) exposure in lung adenocarcinoma (LUAD) via network toxicology, machine learning, and multi-dimensional bioinformatics analysis

Zhiyao Shi,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft

Affiliations The First Clinical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China, Department of Oncology, Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan, Shanxi, China

https://orcid.org/0000-0002-0838-1448

⨯
Zhiyong Fang,

Roles Data curation, Formal analysis, Writing – original draft

Affiliation Department of Oncology, Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Qiang Qin,

Roles Data curation, Formal analysis, Writing – original draft

Affiliation The First Clinical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Yu Gao,

Roles Methodology, Project administration, Resources, Validation

Affiliation Department of Oncology, Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Xi Yang,

Roles Resources, Software, Supervision, Validation, Visualization

Affiliation Department of Oncology, Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Likun Liu,

Roles Project administration, Supervision, Validation, Visualization

Affiliation Department of Oncology, Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Xixing Wang

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: wangxx315@163.com

Affiliation Department of Oncology, Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan, Shanxi, China

https://orcid.org/0000-0003-2444-7248

⨯

Exploring the toxicological mechanisms of Benzo[a]anthracene (BaA) exposure in lung adenocarcinoma (LUAD) via network toxicology, machine learning, and multi-dimensional bioinformatics analysis

Zhiyao Shi,
Zhiyong Fang,
Qiang Qin,
Yu Gao,
Xi Yang,
Likun Liu,
Xixing Wang

Published: February 11, 2026
https://doi.org/10.1371/journal.pone.0340116

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