A non-invasive urinary diagnostic signature for diabetic kidney disease revealed by machine learning and single-cell analysis

Yonggang Chen; Jintai Luo; Yingying Zheng; Xiaomei Jiang; Zixiang Yang; Xiaobing Liu

doi:10.1371/journal.pone.0340096

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Open Access

Peer-reviewed

Research Article

A non-invasive urinary diagnostic signature for diabetic kidney disease revealed by machine learning and single-cell analysis

Yonggang Chen ,

Contributed equally to this work with: Yonggang Chen, Jintai Luo, Yingying Zheng

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Urology, Loudi Central Hospital, Loudi, Hunan Province, China

https://orcid.org/0009-0008-3775-9519

⨯
Jintai Luo ,

Contributed equally to this work with: Yonggang Chen, Jintai Luo, Yingying Zheng

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Department of Urology and Andrology, Minimally Invasive Surgery Center, Guangdong Provincial Key Laboratory of Urology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Loudi Hospital, First Affiliated Hospital of Guangzhou Medical University, Loudi, Hunan Province, China
⨯
Yingying Zheng ,

Contributed equally to this work with: Yonggang Chen, Jintai Luo, Yingying Zheng

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Fangchenggang Hospital of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Fangchenggang, Guangxi, China,
⨯
Xiaomei Jiang,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Data curation

Affiliation Department of Cardiovascular Medicine, Loudi Central Hospital, Loudi, Hunan Province, China
⨯
Zixiang Yang,

Roles Data curation, Formal analysis, Validation, Visualization, Writing – original draft

Affiliation Department of Urology, Loudi Central Hospital, Loudi, Hunan Province, China
⨯
Xiaobing Liu

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: ldlxb216399@163.com

Affiliation Department of Urology, Loudi Central Hospital, Loudi, Hunan Province, China
⨯

A non-invasive urinary diagnostic signature for diabetic kidney disease revealed by machine learning and single-cell analysis

Yonggang Chen,
Jintai Luo,
Yingying Zheng,
Xiaomei Jiang,
Zixiang Yang,
Xiaobing Liu

Published: January 2, 2026
https://doi.org/10.1371/journal.pone.0340096

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Kidneys
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Biomarkers
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Sediment
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Transcriptome analysis
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Urine
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Diagnostic medicine
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Gene expression
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Chronic kidney disease
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