Distinct brain pathways link depressive symptoms due to respiratory dysfunction and reduced physical activity in patients with chronic obstructive pulmonary disease: A single-center observational pilot study

• Shunsuke Sakakura ,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  ¶‡ These authors share co-first authorship on this work.

  Affiliations Department of Physiology, Showa Medical University School of Medicine, Tokyo, Japan, Department of Respiratory Medicine, Showa Medical University Fujigaoka Hospital, Yokohama, Japan

  ⨯
• Motoyasu Honma ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mhonma@med.showa-u.ac.jp

  ¶‡ These authors share co-first authorship on this work.

  Affiliation Department of Physiology, Showa Medical University School of Medicine, Tokyo, Japan

  https://orcid.org/0000-0003-4612-0115

  ⨯
• Yuri Masaoka,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Writing – review & editing

  Affiliation Department of Physiology, Showa Medical University School of Medicine, Tokyo, Japan

  ⨯
• Ryo Manabe,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Medicine, Division of Respiratory Medicine and Allergology, Showa Medical University School of Medicine, Tokyo, Japan

  ⨯
• Kentaro Okuda,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Medicine, Tokyo Metropolitan Ebara Hospital, Tokyo, Japan, Home Care Support Clinic Kaede no Kaze Kawasaki Chuo, Kawasaki, Japan

  ⨯
• Masaki Yoshida,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Orthoptics and Visual Sciences, International University of Health and Welfare, Tokyo, Japan

  ⨯
• Akira Yoshikawa,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Division of Health Science Education, Showa Medical University School of Nursing and Rehabilitation Sciences, Yokohama, Japan

  https://orcid.org/0000-0002-4424-1629

  ⨯
• Misako Matsui,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Physiology, Showa Medical University School of Medicine, Tokyo, Japan

  ⨯
• Daiki Shoji,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Neurology, Showa Medical University School of Medicine, Tokyo, Japan

  ⨯
• Miku Kosuge,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Respiratory Medicine, Showa Medical University Fujigaoka Hospital, Yokohama, Japan

  ⨯
• Shota Kosuge,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Neurology, Showa Medical University School of Medicine, Tokyo, Japan

  ⨯
• Kenta Miyo,

  Roles Formal analysis, Writing – review & editing

  Affiliations Department of Physiology, Showa Medical University School of Medicine, Tokyo, Japan, Department of Respiratory Medicine, Showa Medical University Fujigaoka Hospital, Yokohama, Japan

  ⨯
• Masahiro Ida,

  Roles Formal analysis, Writing – review & editing

  Affiliations Department of Radiology, Stroke Center, Tokyo Metropolitan Ebara Hospital, Tokyo, Japan, Department of Radiology, National Hospital Organization Mito Medical Center, Ibaraki, Japan

  ⨯
• Fumihiro Yamaguchi,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Respiratory Medicine, Showa Medical University Fujigaoka Hospital, Yokohama, Japan

  https://orcid.org/0000-0003-1611-6991

  ⨯
• Takuya Yokoe,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Respiratory Medicine, Showa Medical University Fujigaoka Hospital, Yokohama, Japan

  ⨯
•  [ ... ],
• Masahiko Izumizaki

  Roles Funding acquisition, Supervision, Validation, Writing – review & editing

  Affiliation Department of Physiology, Showa Medical University School of Medicine, Tokyo, Japan

  ⨯
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