Overexpression of EMT-related transcription factors SNAI1 and ZEB1 is associated with more aggressive clinicopathological features of pancreatic cancer

Kestutis Urbonas; Gabija Stachneviciute; Aldona Jasukaitiene; Povilas Ignatavicius; Zilvinas Dambrauskas; Antanas Gulbinas; Giedrius Barauskas

doi:10.1371/journal.pone.0339964

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Open Access

Peer-reviewed

Research Article

Overexpression of EMT-related transcription factors SNAI1 and ZEB1 is associated with more aggressive clinicopathological features of pancreatic cancer

Kestutis Urbonas ,

Roles Formal analysis, Investigation, Methodology, Writing – original draft

* E-mail: kestutis.urbonas@lsmu.lt

Affiliations Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania, Institute for Digestive Research, Laboratory of Surgical Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania

https://orcid.org/0000-0002-8055-3945

⨯
Gabija Stachneviciute,

Roles Data curation, Formal analysis, Investigation

Affiliation Institute for Digestive Research, Laboratory of Surgical Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania
⨯
Aldona Jasukaitiene,

Roles Data curation, Investigation, Methodology

Affiliation Institute for Digestive Research, Laboratory of Surgical Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania
⨯
Povilas Ignatavicius,

Roles Supervision, Validation

Affiliations Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania, Institute for Digestive Research, Laboratory of Surgical Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania
⨯
Zilvinas Dambrauskas,

Roles Conceptualization, Supervision, Validation

Affiliations Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania, Institute for Digestive Research, Laboratory of Surgical Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania
⨯
Antanas Gulbinas,

Roles Conceptualization, Resources, Supervision

Affiliation Institute for Digestive Research, Laboratory of Surgical Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania
⨯
Giedrius Barauskas

Roles Resources, Supervision

Affiliation Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania

https://orcid.org/0000-0002-4321-7280

⨯

Overexpression of EMT-related transcription factors SNAI1 and ZEB1 is associated with more aggressive clinicopathological features of pancreatic cancer

Kestutis Urbonas,
Gabija Stachneviciute,
Aldona Jasukaitiene,
Povilas Ignatavicius,
Zilvinas Dambrauskas,
Antanas Gulbinas,
Giedrius Barauskas

Published: January 2, 2026
https://doi.org/10.1371/journal.pone.0339964

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Pancreatic cancer
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Transcription factors
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Gene expression
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Metastasis
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Transcriptional control
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