-
Loading metrics
Open Access
Peer-reviewed
Research Article
The KEAP1/NRF2 axis controls LPS-induced oxidative stress, inflammasome activation and caspase-1 activity in human endothelial cells
-
Alba Montero-Jodra,
Roles Formal analysis, Investigation, Methodology, Writing – original draft
Affiliations Department of Surgery, University of Valladolid, Valladolid, Spain, Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), Superior Council for Scientific Research (CSIC) – University of Valladolid (UVa), Valladolid, Spain
⨯ -
Maria Jesús Estebán-Amo,
Roles Methodology
Affiliations Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), Superior Council for Scientific Research (CSIC) – University of Valladolid (UVa), Valladolid, Spain, Department of Cell Biology, Genetics, Histology and Pharmacology, University of Valladolid, Valladolid, Spain
⨯ -
Silvia Patricia Fernández-Martínez,
Roles Funding acquisition, Methodology
Affiliation Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), Superior Council for Scientific Research (CSIC) – University of Valladolid (UVa), Valladolid, Spain
⨯ -
César García Martínez,
Roles Investigation
Affiliations Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), Superior Council for Scientific Research (CSIC) – University of Valladolid (UVa), Valladolid, Spain, Department of Cell Biology, Genetics, Histology and Pharmacology, University of Valladolid, Valladolid, Spain
⨯ -
Miguel Ángel de la Fuente García,
Roles Funding acquisition, Supervision
Affiliations Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), Superior Council for Scientific Research (CSIC) – University of Valladolid (UVa), Valladolid, Spain, Department of Cell Biology, Genetics, Histology and Pharmacology, University of Valladolid, Valladolid, Spain
⨯ -
Adrián García-Concejo,
Roles Methodology
Affiliation Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain
⨯ -
Marta Martín-Fernández,
Roles Supervision
Affiliations Department of Cell Biology, Genetics, Histology and Pharmacology, University of Valladolid, Valladolid, Spain, BioCritic, Group for Biomedical Research in Critical Care Medicine, Valladolid, Spain, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain
⨯ -
Eduardo Tamayo ,
Contributed equally to this work with: Eduardo Tamayo, María Simarro
Roles Funding acquisition, Supervision
Affiliations Department of Surgery, University of Valladolid, Valladolid, Spain, BioCritic, Group for Biomedical Research in Critical Care Medicine, Valladolid, Spain, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain, Department of Anaesthesiology & Critical Care, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
⨯ -
María Simarro
Contributed equally to this work with: Eduardo Tamayo, María Simarro
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
* E-mail: msimarrogrande@gmail.com
Affiliations Unit of Excellence, Institute of Biomedicine and Molecular Genetics (IBGM), Superior Council for Scientific Research (CSIC) – University of Valladolid (UVa), Valladolid, Spain, Department of Cell Biology, Genetics, Histology and Pharmacology, University of Valladolid, Valladolid, Spain
⨯
The KEAP1/NRF2 axis controls LPS-induced oxidative stress, inflammasome activation and caspase-1 activity in human endothelial cells
- Alba Montero-Jodra,
- Maria Jesús Estebán-Amo,
- Silvia Patricia Fernández-Martínez,
- César García Martínez,
- Miguel Ángel de la Fuente García,
- Adrián García-Concejo,
- Marta Martín-Fernández,
- Eduardo Tamayo,
- María Simarro
- Published: February 4, 2026
- https://doi.org/10.1371/journal.pone.0339928