Exploring the crosstalk between the FGF/FGFR pathway and tumor microenvironment in clear cell renal cell carcinoma

Takafumi Narisawa; Sei Naito; Yoshihide Mitsuda; Rintaro Ohe; Hidenori Sato; Chizuru Kobayashi; Yuki Miyano; Hiromi Ito; Mitsuru Futakuchi; Norihiko Tsuchiya

doi:10.1371/journal.pone.0339888

Loading metrics

Open Access

Peer-reviewed

Research Article

Exploring the crosstalk between the FGF/FGFR pathway and tumor microenvironment in clear cell renal cell carcinoma

Takafumi Narisawa ,

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Writing – original draft

* E-mail: tnari_0623@yahoo.co.jp

Affiliation Department of Urology, Faculty of Medicine, Yamagata University, Yamagata, Japan

https://orcid.org/0000-0003-4062-2675

⨯
Sei Naito,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources

Affiliation Department of Urology, Faculty of Medicine, Yamagata University, Yamagata, Japan
⨯
Yoshihide Mitsuda,

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

Affiliation Medical Headquarters, Eisai Co., Ltd., Tokyo, Japan
⨯
Rintaro Ohe,

Roles Investigation, Resources

Affiliation Department of Pathology, Faculty of Medicine, Yamagata University, Yamagata, Japan

https://orcid.org/0000-0002-8035-791X

⨯
Hidenori Sato,

Roles Investigation, Resources, Supervision

Affiliation Division of Multi-omics Research, Yamagata University Well-Being Institute, Yamagata, Japan
⨯
Chizuru Kobayashi,

Roles Data curation, Formal analysis, Software, Validation, Visualization

Affiliation Deep Human Biology Learning, Eisai Co., Ltd., Tokyo, Japan

https://orcid.org/0009-0009-5655-8111

⨯
Yuki Miyano,

Roles Investigation, Resources

Affiliation Division of Multi-omics Research, Yamagata University Well-Being Institute, Yamagata, Japan
⨯
Hiromi Ito,

Roles Investigation, Resources

Affiliation Department of Urology, Faculty of Medicine, Yamagata University, Yamagata, Japan
⨯
Mitsuru Futakuchi,

Roles Supervision

Affiliation Department of Pathology, Faculty of Medicine, Yamagata University, Yamagata, Japan

https://orcid.org/0000-0001-8647-583X

⨯
Norihiko Tsuchiya

Roles Conceptualization, Supervision

Affiliation Department of Urology, Faculty of Medicine, Yamagata University, Yamagata, Japan
⨯

Exploring the crosstalk between the FGF/FGFR pathway and tumor microenvironment in clear cell renal cell carcinoma

Takafumi Narisawa,
Sei Naito,
Yoshihide Mitsuda,
Rintaro Ohe,
Hidenori Sato,
Chizuru Kobayashi,
Yuki Miyano,
Hiromi Ito,
Mitsuru Futakuchi,
Norihiko Tsuchiya

Published: February 10, 2026
https://doi.org/10.1371/journal.pone.0339888

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Fibroblast growth factor
Is the Subject Area "Fibroblast growth factor" applicable to this article?

Thanks for your feedback.
Metastasis
Is the Subject Area "Metastasis" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Renal cancer
Is the Subject Area "Renal cancer" applicable to this article?

Thanks for your feedback.
Renal cell carcinoma
Is the Subject Area "Renal cell carcinoma" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Gastric cancer
Is the Subject Area "Gastric cancer" applicable to this article?

Thanks for your feedback.
Immunosuppressives
Is the Subject Area "Immunosuppressives" applicable to this article?

Thanks for your feedback.