DC-STAMP activates the PI3K/AKT/mTOR signaling pathway to regulate PANoptosis in acute myeloid leukemia

Qian Liang; Biao Li; Yue Li; Longhui Ma; Li Dong; Ning Ding; Wei Zhang; Haoran Wang; Junying Liu

doi:10.1371/journal.pone.0339670

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Open Access

Peer-reviewed

Research Article

DC-STAMP activates the PI3K/AKT/mTOR signaling pathway to regulate PANoptosis in acute myeloid leukemia

Qian Liang,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Hematology, Zhoukou Central Hospital, Zhoukou Medical Science Research Center, Zhoukou, China
⨯
Biao Li,

Roles Formal analysis, Software, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Cerebral Interventional Therapy, Zhoukou Central Hospital, Zhoukou Medical Science Research Center, Zhoukou, China
⨯
Yue Li,

Roles Formal analysis, Software, Supervision, Writing – review & editing

Affiliation Teaching Management Section, Zhoukou Central Hospital, Zhoukou Medical Science Research Center, Zhoukou, China
⨯
Longhui Ma,

Roles Data curation, Software, Supervision, Writing – review & editing

Affiliation Teaching Management Section, Zhoukou Central Hospital, Zhoukou Medical Science Research Center, Zhoukou, China
⨯
Li Dong,

Roles Software, Writing – review & editing

Affiliation Department of Hematology, Zhoukou Central Hospital, Zhoukou Medical Science Research Center, Zhoukou, China
⨯
Ning Ding,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Teaching Management Section, Zhoukou Central Hospital, Zhoukou Medical Science Research Center, Zhoukou, China
⨯
Wei Zhang,

Roles Data curation, Writing – review & editing

Affiliation Teaching Management Section, Zhoukou Central Hospital, Zhoukou Medical Science Research Center, Zhoukou, China
⨯
Haoran Wang,

Roles Investigation, Writing – review & editing

Affiliation Teaching Management Section, Zhoukou Central Hospital, Zhoukou Medical Science Research Center, Zhoukou, China
⨯
Junying Liu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

* E-mail: kjk1796@163.com

Affiliation Department of Gastroenterology, Zhoukou Central Hospital, Zhoukou Medical Science Research Center, Zhoukou, China

https://orcid.org/0009-0003-4569-2346

⨯

DC-STAMP activates the PI3K/AKT/mTOR signaling pathway to regulate PANoptosis in acute myeloid leukemia

Qian Liang,
Biao Li,
Yue Li,
Longhui Ma,
Li Dong,
Ning Ding,
Wei Zhang,
Haoran Wang,
Junying Liu

Published: January 16, 2026
https://doi.org/10.1371/journal.pone.0339670

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Apoptosis
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Acute myeloid leukemia
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Flow cytometry
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Gene expression
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Regulator genes
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Small interfering RNA
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