Sucrose but not arsenic induce hepatic steatosis which correlates with calpain-1 inhibition

Myrian Velasco; Rosa Isela Ortiz-Huidobro; Ana María Salazar; Marcia Hiriart; Patricia Ostrosky-Wegman; Pablo Pánico

doi:10.1371/journal.pone.0339586

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Open Access

Peer-reviewed

Research Article

Sucrose but not arsenic induce hepatic steatosis which correlates with calpain-1 inhibition

Myrian Velasco,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Cognitive Neurosciences, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico
⨯
Rosa Isela Ortiz-Huidobro,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico
⨯
Ana María Salazar,

Roles Funding acquisition, Methodology, Resources, Writing – review & editing

Affiliation Department of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico
⨯
Marcia Hiriart,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – review & editing

Affiliation Department of Cognitive Neurosciences, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

https://orcid.org/0000-0001-5711-8868

⨯
Patricia Ostrosky-Wegman ,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: ostrosky@biomedicas.unam.mx (PO-W); panicopablo@gmail.com (PP)

Affiliation Department of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico
⨯
Pablo Pánico

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft

* E-mail: ostrosky@biomedicas.unam.mx (PO-W); panicopablo@gmail.com (PP)

Affiliation Department of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico

https://orcid.org/0000-0002-9669-4224

⨯

Sucrose but not arsenic induce hepatic steatosis which correlates with calpain-1 inhibition

Myrian Velasco,
Rosa Isela Ortiz-Huidobro,
Ana María Salazar,
Marcia Hiriart,
Patricia Ostrosky-Wegman,
Pablo Pánico

Published: December 30, 2025
https://doi.org/10.1371/journal.pone.0339586

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Arsenic
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Fatty liver
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Sucrose
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Steatosis
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Lipids
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Calpain inhibitors
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Hepatocytes
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Protein abundance
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