In-silico characterization of deleterious non-synonymous SNPs in the human S1PR1 gene reveals structural instability and altered ligand affinity

• Sangram Biswas,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation Department of Biotechnology, Bangladesh Agricultural University, Mymensingh, Bangladesh

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• Dipankar Sardar,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft

  Affiliation Department of Biotechnology, Bangladesh Agricultural University, Mymensingh, Bangladesh

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• Md. Arju Hossain,

  Roles Conceptualization, Investigation, Project administration, Validation, Visualization, Writing – review & editing

  Affiliation Department of Biochemistry and Biotechnology, Khwaja Yunus Ali University, Sirajganj, Bangladesh

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• Soharth Hasnat,

  Roles Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft

  Affiliation Molecular Biology and Bioinformatics Laboratory, Department of Gynecology, Obstetrics and Reproductive Health, Gazipur Agricultural University, Gazipur, Bangladesh

  https://orcid.org/0009-0008-3595-1179

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• Arif Hossain Ramjan,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Department of Pharmacy, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh

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• Ummah Kulsum Nazifa,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Biotechnology, Bangladesh Agricultural University, Mymensingh, Bangladesh

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• Fatema-Tuz Zohora,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Biotechnology, Bangladesh Agricultural University, Mymensingh, Bangladesh

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• Ishrat Jahan Esha,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Biotechnology, Bangladesh Agricultural University, Mymensingh, Bangladesh

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• Chandrika Mondal,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Fisheries Biology and Genetics, Bangladesh Agricultural University, Mymensingh, Bangladesh

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• Abdul Barik,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – original draft

  Affiliation Department of Biotechnology, Bangladesh Agricultural University, Mymensingh, Bangladesh

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• M. Nazmul Hoque

  Roles Conceptualization, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – review & editing

  * E-mail: nazmul90@gau.edu.bd

  Affiliation Molecular Biology and Bioinformatics Laboratory, Department of Gynecology, Obstetrics and Reproductive Health, Gazipur Agricultural University, Gazipur, Bangladesh

  https://orcid.org/0000-0002-4861-0030

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