Identification of hypoxia- and mitophagy-related diagnostic biomarkers for ulcerative colitis based on bioinformatic analysis and machine learning

Zewei Sheng; Lun Zhao; Yu Fu; Xuefeng Liu; Yuyu Peng; Yangling Huang; Yuhan Jian; Yanlin Zhu; Yuedong Liu

doi:10.1371/journal.pone.0339296

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Open Access

Peer-reviewed

Research Article

Identification of hypoxia- and mitophagy-related diagnostic biomarkers for ulcerative colitis based on bioinformatic analysis and machine learning

Zewei Sheng ,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

* E-mail: 13998359001@126.com (YL); 937511258@qq.com (ZS)

¶‡ ZS and LZ are co-first authors and contributed equally to this work.

Affiliations Third Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China, Third Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China

https://orcid.org/0009-0008-6038-8998

⨯
Lun Zhao ,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

¶‡ ZS and LZ are co-first authors and contributed equally to this work.

Affiliation Third Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
⨯
Yu Fu,

Roles Data curation, Software

Affiliation College of Acupuncture–Moxibustion and Massage, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
⨯
Xuefeng Liu,

Roles Data curation, Software

Affiliations Third Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China, Third Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
⨯
Yuyu Peng,

Roles Software

Affiliations Third Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China, Third Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
⨯
Yangling Huang,

Roles Software

Affiliation Technology Center, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
⨯
Yuhan Jian,

Roles Writing – review & editing

Affiliations Third Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China, Third Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
⨯
Yanlin Zhu,

Roles Writing – review & editing

Affiliations Third Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China, Third Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
⨯
Yuedong Liu

Roles Funding acquisition, Supervision

* E-mail: 13998359001@126.com (YL); 937511258@qq.com (ZS)

Affiliations Third Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China, Third Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
⨯

Identification of hypoxia- and mitophagy-related diagnostic biomarkers for ulcerative colitis based on bioinformatic analysis and machine learning

Zewei Sheng,
Lun Zhao,
Yu Fu,
Xuefeng Liu,
Yuyu Peng,
Yangling Huang,
Yuhan Jian,
Yanlin Zhu,
Yuedong Liu

Published: January 21, 2026
https://doi.org/10.1371/journal.pone.0339296

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Immune cells
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Gene expression
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Hypoxia
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