Randomized controlled trial comparing low pressure (8 mmHg) versus high pressure (14 mmHg) CO2 insufflation on postoperative pain in patients undergoing laparoscopic cholecystectomy: Protocol

Amine Ben Safta; Salsabil Nasri; Imen Samaali; Hajer Taher; Mohamed Mehdi Trabelsi; Chadli Dziri; Wajih Dougaz; Ramzi Nouira

doi:10.1371/journal.pone.0339161

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Randomized controlled trial comparing low pressure (8 mmHg) versus high pressure (14 mmHg) CO2 insufflation on postoperative pain in patients undergoing laparoscopic cholecystectomy: Protocol

Amine Ben Safta,

Roles Data curation, Formal analysis, Writing – original draft

Affiliations Department of Digestive Surgery B, Charles Nicolle University Hospital, Tunis, Tunisia,, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
⨯
Salsabil Nasri ,

Roles Data curation, Formal analysis, Writing – original draft

* E-mail: salsabil_nasri@yahoo.fr

Affiliations Department of Digestive Surgery B, Charles Nicolle University Hospital, Tunis, Tunisia,, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia

https://orcid.org/0000-0001-9565-3562

⨯
Imen Samaali,

Roles Conceptualization, Methodology, Validation, Writing – review & editing

Affiliations Department of Digestive Surgery B, Charles Nicolle University Hospital, Tunis, Tunisia,, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
⨯
Hajer Taher,

Roles Data curation, Formal analysis

Affiliations Department of Digestive Surgery B, Charles Nicolle University Hospital, Tunis, Tunisia,, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
⨯
Mohamed Mehdi Trabelsi,

Roles Data curation, Formal analysis

Affiliations Department of Digestive Surgery B, Charles Nicolle University Hospital, Tunis, Tunisia,, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
⨯
Chadli Dziri,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

Affiliations Department of Digestive Surgery B, Charles Nicolle University Hospital, Tunis, Tunisia,, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
⨯
Wajih Dougaz,

Roles Conceptualization, Methodology, Validation, Writing – review & editing

Affiliations Department of Digestive Surgery B, Charles Nicolle University Hospital, Tunis, Tunisia,, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
⨯
Ramzi Nouira

Roles Conceptualization, Validation, Writing – review & editing

Affiliations Department of Digestive Surgery B, Charles Nicolle University Hospital, Tunis, Tunisia,, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
⨯

Randomized controlled trial comparing low pressure (8 mmHg) versus high pressure (14 mmHg) CO2 insufflation on postoperative pain in patients undergoing laparoscopic cholecystectomy: Protocol

Amine Ben Safta,
Salsabil Nasri,
Imen Samaali,
Hajer Taher,
Mohamed Mehdi Trabelsi,
Chadli Dziri,
Wajih Dougaz,
Ramzi Nouira

Published: December 18, 2025
https://doi.org/10.1371/journal.pone.0339161

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Pain
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Abdominal pain
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Laparoscopic cholecystectomy
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