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Open Access
Peer-reviewed
Research Article
Proteomic screening of TMEM43 binding partners identifies VDAC leading to mitochondrial dysfunction
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Qingqing Zhu ,
Contributed equally to this work with: Qingqing Zhu, Guoxing Zheng, Yingsi Lu
Roles Data curation, Methodology, Validation, Visualization
Affiliation Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
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Guoxing Zheng ,
Contributed equally to this work with: Qingqing Zhu, Guoxing Zheng, Yingsi Lu
Roles Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: zhuchm3@mail.sysu.edu.cn (CZ); zhangjian@sustech.edu.cn (JZ); opqsky@126.com (GZ); luy3@sustech.edu.cn (LY)
Affiliation Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
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Yingsi Lu ,
Contributed equally to this work with: Qingqing Zhu, Guoxing Zheng, Yingsi Lu
Roles Funding acquisition, Resources, Data curation, Investigation, Methodology, Validation
Affiliation Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
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Yizhou Jiang,
Roles Formal analysis, Investigation
Affiliation Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, China
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Yan Li,
Roles Data curation, Investigation
Affiliation Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
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Hong Chen,
Roles Investigation, Validation
Affiliation Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
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Lifen Huang,
Roles Investigation
Affiliation Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
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Nannan Tang,
Roles Investigation
Affiliation Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
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Bo Li,
Roles Writing – review & editing
Affiliation Guangdong Provincial Key Laboratory of Digestive Cancer Research, Guangdong-Hong Kong-Macau University Joint Laboratory of Digestive Cancer Research, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Guangdong, Guangdong, China
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Yi Lu ,
* E-mail: zhuchm3@mail.sysu.edu.cn (CZ); zhangjian@sustech.edu.cn (JZ); opqsky@126.com (GZ); luy3@sustech.edu.cn (LY)
Affiliation School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China
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Jian Zhang ,
Roles Funding acquisition, Resources
* E-mail: zhuchm3@mail.sysu.edu.cn (CZ); zhangjian@sustech.edu.cn (JZ); opqsky@126.com (GZ); luy3@sustech.edu.cn (LY)
Affiliation School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China
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Chengming Zhu
Roles Conceptualization, Funding acquisition, Resources, Supervision
* E-mail: zhuchm3@mail.sysu.edu.cn (CZ); zhangjian@sustech.edu.cn (JZ); opqsky@126.com (GZ); luy3@sustech.edu.cn (LY)
Affiliation Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
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Proteomic screening of TMEM43 binding partners identifies VDAC leading to mitochondrial dysfunction
- Qingqing Zhu,
- Guoxing Zheng,
- Yingsi Lu,
- Yizhou Jiang,
- Yan Li,
- Hong Chen,
- Lifen Huang,
- Nannan Tang,
- Bo Li,
- Yi Lu
- Published: December 18, 2025
- https://doi.org/10.1371/journal.pone.0339129