Nicotinamide mononucleotide improves spermatogenesis in aluminium-exposed mice by inhibiting NLRP3-mediated pyroptosis

Weihua Nong; Qiumei Huang; Sheng Dou; Yanhong Wei; Yanlun Song; Junli Wang; Xiaocan Lei; Fenglian Yang; Liqiao He

doi:10.1371/journal.pone.0339020

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Open Access

Peer-reviewed

Research Article

Nicotinamide mononucleotide improves spermatogenesis in aluminium-exposed mice by inhibiting NLRP3-mediated pyroptosis

Weihua Nong ,

Contributed equally to this work with: Weihua Nong, Qiumei Huang

Roles Validation, Writing – original draft

Affiliations Department of Obstetrics and Gynecology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China, Reproductive Medicine, Guangxi Medical and Health Key Discipline Construction Project of the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
⨯
Qiumei Huang ,

Contributed equally to this work with: Weihua Nong, Qiumei Huang

Roles Visualization, Writing – original draft

Affiliation Youjiang Medical University for Nationalities, Baise, China

https://orcid.org/0009-0007-2723-3516

⨯
Sheng Dou,

Roles Conceptualization, Validation

Affiliation Youjiang Medical University for Nationalities, Baise, China
⨯
Yanhong Wei,

Roles Data curation

Affiliation Youjiang Medical University for Nationalities, Baise, China
⨯
Yanlun Song,

Roles Software

Affiliation Youjiang Medical University for Nationalities, Baise, China
⨯
Junli Wang,

Roles Conceptualization, Writing – review & editing

Affiliation Reproductive Medicine, Guangxi Medical and Health Key Discipline Construction Project of the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
⨯
Xiaocan Lei,

Roles Conceptualization

Affiliation Department of Histology and Embryology, Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, China
⨯
Fenglian Yang ,

Roles Conceptualization, Writing – review & editing

* E-mail: yangfenglian303@126.com (FY); heliqiao7876@sina.com (LH)

Affiliation College of Pharmacy, Youjiang Medical University for Nationalities, Baise, China
⨯
Liqiao He

Roles Conceptualization, Resources, Writing – review & editing

* E-mail: yangfenglian303@126.com (FY); heliqiao7876@sina.com (LH)

Affiliation Department of Obstetrics and Gynecology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
⨯

Nicotinamide mononucleotide improves spermatogenesis in aluminium-exposed mice by inhibiting NLRP3-mediated pyroptosis

Weihua Nong,
Qiumei Huang,
Sheng Dou,
Yanhong Wei,
Yanlun Song,
Junli Wang,
Xiaocan Lei,
Fenglian Yang,
Liqiao He

Published: January 22, 2026
https://doi.org/10.1371/journal.pone.0339020

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Aluminum
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