Biopsychosocial factors associated with symptom severity in the overlap of non-erosive reflux disease and epigastric pain syndrome: A multicenter cross-sectional study

Mi Lv; Hui Che; Jiayan Hu; Wenxi Yu; Zhaoxia Liu; Xiaolin Zhou; Binduo Zhou; Jinyi Xie; Fengyun Wang

doi:10.1371/journal.pone.0338971

Loading metrics

Open Access

Peer-reviewed

Research Article

Biopsychosocial factors associated with symptom severity in the overlap of non-erosive reflux disease and epigastric pain syndrome: A multicenter cross-sectional study

Mi Lv,

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft

Affiliation Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Hui Che,

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Jiayan Hu,

Roles Investigation, Methodology, Software

Affiliation Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China
⨯
Wenxi Yu,

Roles Investigation, Methodology, Software

Affiliation Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Zhaoxia Liu,

Roles Data curation, Investigation, Writing – review & editing

Affiliation The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China,
⨯
Xiaolin Zhou,

Roles Investigation, Writing – review & editing

Affiliation Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
⨯
Binduo Zhou,

Roles Investigation, Writing – review & editing

Affiliation Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medicine Hospital), Liuzhou, Guangxi, China
⨯
Jinyi Xie,

Roles Data curation, Funding acquisition, Supervision, Validation, Writing – review & editing

Affiliation Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Fengyun Wang

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – review & editing

^{^*} 18810631761@163.com

Affiliation Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China

https://orcid.org/0009-0009-3515-9162

⨯

Biopsychosocial factors associated with symptom severity in the overlap of non-erosive reflux disease and epigastric pain syndrome: A multicenter cross-sectional study

Mi Lv,
Hui Che,
Jiayan Hu,
Wenxi Yu,
Zhaoxia Liu,
Xiaolin Zhou,
Binduo Zhou,
Jinyi Xie,
Fengyun Wang

Published: December 15, 2025
https://doi.org/10.1371/journal.pone.0338971

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Sleep
Is the Subject Area "Sleep" applicable to this article?

Thanks for your feedback.
Clinical psychology
Is the Subject Area "Clinical psychology" applicable to this article?

Thanks for your feedback.
Labor history
Is the Subject Area "Labor history" applicable to this article?

Thanks for your feedback.
Gastrointestinal analysis
Is the Subject Area "Gastrointestinal analysis" applicable to this article?

Thanks for your feedback.
Linear regression analysis
Is the Subject Area "Linear regression analysis" applicable to this article?

Thanks for your feedback.
Abdominal surgery
Is the Subject Area "Abdominal surgery" applicable to this article?

Thanks for your feedback.
Gastroesophageal reflux disease
Is the Subject Area "Gastroesophageal reflux disease" applicable to this article?

Thanks for your feedback.
Psychometrics
Is the Subject Area "Psychometrics" applicable to this article?

Thanks for your feedback.