Discovery of F-18 labeled repurposed CNS drugs by computational strategy for effective tau imaging and alzheimer’s diagnosis

Pan Tang; Xuehua Chen; Pingping Li; Ling Zhang; Bin Tang; Jun Wen; Yan Liu; Iqra Kalsoom; Chong Cheng

doi:10.1371/journal.pone.0338901

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Open Access

Peer-reviewed

Research Article

Discovery of F-18 labeled repurposed CNS drugs by computational strategy for effective tau imaging and alzheimer’s diagnosis

Pan Tang,

Roles Formal analysis, Methodology, Validation, Writing – review & editing

Affiliation Department of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde), Changde, China
⨯
Xuehua Chen,

Roles Software, Visualization, Writing – original draft

Affiliation Department of Nuclear Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde), Changde, China
⨯
Pingping Li,

Roles Software, Validation, Visualization

Affiliation Department of Paediatrics, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde), Changde, China
⨯
Ling Zhang,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Centre for Reproductive Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde), Changde, China
⨯
Bin Tang,

Roles Conceptualization, Investigation, Validation

Affiliation Centre for Reproductive Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde), Changde, China
⨯
Jun Wen,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde), Changde, China
⨯
Yan Liu,

Roles Software, Validation, Visualization

Affiliation Department of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde), Changde, China
⨯
Iqra Kalsoom,

Roles Formal analysis, Methodology, Software, Supervision, Writing – review & editing

Affiliation School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China
⨯
Chong Cheng

Roles Funding acquisition, Resources, Supervision

* E-mail: j001cg@163.com

Affiliation Department of Nuclear Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde), Changde, China

https://orcid.org/0009-0004-2572-5355

⨯

Discovery of F-18 labeled repurposed CNS drugs by computational strategy for effective tau imaging and alzheimer’s diagnosis

Pan Tang,
Xuehua Chen,
Pingping Li,
Ling Zhang,
Bin Tang,
Jun Wen,
Yan Liu,
Iqra Kalsoom,
Chong Cheng

Published: December 22, 2025
https://doi.org/10.1371/journal.pone.0338901

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Drug interactions
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Alzheimer's disease
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Tau protein
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Positron emission tomography
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Blood-brain barrier
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