Multi-omics analysis reveals diagnostic and therapeutic biomarkers for aging phenotypes in ulcerative colitis

Lei Guo; Jun Ge; Li Cheng; Xinyi Zhang; Zhengzheng Wu; Meili Liu; Hanmei Jiang; Wei Gong; Yi Liu

doi:10.1371/journal.pone.0338880

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Open Access

Peer-reviewed

Research Article

Multi-omics analysis reveals diagnostic and therapeutic biomarkers for aging phenotypes in ulcerative colitis

Lei Guo,

Roles Writing – original draft, Writing – review & editing

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China, Pharmaceutical plant industry-university collaborative research center, Hubei University of Chinese Medicine, Wuhan, China

https://orcid.org/0009-0006-9773-4829

⨯
Jun Ge,

Roles Data curation

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China, Pharmaceutical plant industry-university collaborative research center, Hubei University of Chinese Medicine, Wuhan, China
⨯
Li Cheng,

Roles Data curation

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China, Pharmaceutical plant industry-university collaborative research center, Hubei University of Chinese Medicine, Wuhan, China
⨯
Xinyi Zhang,

Roles Data curation

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China, Pharmaceutical plant industry-university collaborative research center, Hubei University of Chinese Medicine, Wuhan, China
⨯
Zhengzheng Wu,

Roles Investigation

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China, Pharmaceutical plant industry-university collaborative research center, Hubei University of Chinese Medicine, Wuhan, China
⨯
Meili Liu,

Roles Investigation

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China, Pharmaceutical plant industry-university collaborative research center, Hubei University of Chinese Medicine, Wuhan, China
⨯
Hanmei Jiang,

Roles Data curation

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China, Pharmaceutical plant industry-university collaborative research center, Hubei University of Chinese Medicine, Wuhan, China
⨯
Wei Gong ,

Roles Validation

* E-mail: 1069@hbucm.edu.cn

Affiliation Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, China
⨯
Yi Liu

Roles Writing – review & editing

* E-mail: 1069@hbucm.edu.cn

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China, Pharmaceutical plant industry-university collaborative research center, Hubei University of Chinese Medicine, Wuhan, China
⨯

Multi-omics analysis reveals diagnostic and therapeutic biomarkers for aging phenotypes in ulcerative colitis

Lei Guo,
Jun Ge,
Li Cheng,
Xinyi Zhang,
Zhengzheng Wu,
Meili Liu,
Hanmei Jiang,
Wei Gong,
Yi Liu

Published: December 17, 2025
https://doi.org/10.1371/journal.pone.0338880

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