Sestrin3 confers resistance to recombinant human arginase in small cell lung cancer by activating Akt/mTOR/ASS1 axis

Zhongqiang Zhang; Zizhe Lin; Weishan Li; Binxiong Chen; Yueming Liu; Hanchao Gao; Shi Xu

doi:10.1371/journal.pone.0338802

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Open Access

Peer-reviewed

Research Article

Sestrin3 confers resistance to recombinant human arginase in small cell lung cancer by activating Akt/mTOR/ASS1 axis

Zhongqiang Zhang ,

Roles Data curation

¶‡ These authors contributed equally to this work and share first authorship.

Affiliations Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China, Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China
⨯
Zizhe Lin ,

Roles Data curation

¶‡ These authors contributed equally to this work and share first authorship.

Affiliations Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China, Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China
⨯
Weishan Li,

Roles Data curation, Formal analysis

Affiliation Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China
⨯
Binxiong Chen,

Roles Methodology

Affiliation Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China
⨯
Yueming Liu,

Roles Methodology, Supervision

Affiliation Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China
⨯
Hanchao Gao ,

Roles Conceptualization, Supervision

* E-mail: xushi_cn@163.com (SX); hcgao@foxmail.com (HG)

Affiliations Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China, Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen Longhua District Key Laboratory for Diagnosis and Treatment of Chronic Kidney Disease, Shenzhen, Guangdon, China
⨯
Shi Xu

Roles Conceptualization, Project administration, Writing – original draft, Writing – review & editing

* E-mail: xushi_cn@163.com (SX); hcgao@foxmail.com (HG)

Affiliations Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China, Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China

https://orcid.org/0000-0002-2178-5666

⨯

Sestrin3 confers resistance to recombinant human arginase in small cell lung cancer by activating Akt/mTOR/ASS1 axis

Zhongqiang Zhang,
Zizhe Lin,
Weishan Li,
Binxiong Chen,
Yueming Liu,
Hanchao Gao,
Shi Xu

Published: December 29, 2025
https://doi.org/10.1371/journal.pone.0338802

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Small cell lung cancer
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Arginine
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Apoptosis
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Cancer treatment
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Cancers and neoplasms
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Flow cytometry
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Hepatocellular carcinoma
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