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Open Access
Peer-reviewed
Research Article
Laminin N-terminus α31 regulates corneal epithelial cell adhesion and migration through modifying the organization and proteolytic processing of laminin 332
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Lee D. Troughton ,
Contributed equally to this work with: Lee D. Troughton
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing
Affiliation Department of Ophthalmology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America
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Valentina Iorio ,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft
* E-mail: khamill@liverpool.ac.uk (KJH); v.iorio@liverpool.ac.uk (VI)
Affiliation Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
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Liam Shaw,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom
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Conor J. Sugden,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom
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Natasha D. Chavda,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom
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Peter Wilson,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom
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Djamilla Simoens,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation Department of Ophthalmology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America
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Andrea E. Conway,
Roles Formal analysis, Writing – review & editing
Affiliation Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom
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Stefano Sala,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America
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Simon Kaja,
Roles Funding acquisition, Resources, Writing – review & editing
Affiliation Department of Ophthalmology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America
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Kazuhiro Yamamoto,
Roles Funding acquisition, Methodology, Resources, Writing – review & editing
Affiliations Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom, Scleroprotein and Leather Institute, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan
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Kevin J. Hamill
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: khamill@liverpool.ac.uk (KJH); v.iorio@liverpool.ac.uk (VI)
Affiliation Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom
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Laminin N-terminus α31 regulates corneal epithelial cell adhesion and migration through modifying the organization and proteolytic processing of laminin 332
- Lee D. Troughton,
- Valentina Iorio,
- Liam Shaw,
- Conor J. Sugden,
- Natasha D. Chavda,
- Peter Wilson,
- Djamilla Simoens,
- Andrea E. Conway,
- Stefano Sala,
- Simon Kaja
- Published: January 13, 2026
- https://doi.org/10.1371/journal.pone.0338797