The innate immune IMD pathway is a key regulator of gut microbiome and metabolic homeostasis in the black tiger shrimp (Penaeus monodon)

Premruethai Supungul; Sureerat Tang; Tanaporn Uengwetwanit; Umaporn Uawisetwathana; Pacharaporn Angthong; Sopacha Arayamethakorn; Phimsucha Bunphimpapha; Panyisa Potibut; Waraporn Jangsutthivorawat; Virak Visudtiphole; Sage Chaiyapechara; Wanilada Rungrassamee

doi:10.1371/journal.pone.0338796

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Open Access

Peer-reviewed

Research Article

The innate immune IMD pathway is a key regulator of gut microbiome and metabolic homeostasis in the black tiger shrimp (Penaeus monodon)

Premruethai Supungul,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliation Aquatic Molecular Genetics and Biotechnology Research Team, Integrative Aquaculture Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand
⨯
Sureerat Tang,

Roles Formal analysis, Investigation, Writing – original draft

Affiliation Aquatic Molecular Genetics and Biotechnology Research Team, Integrative Aquaculture Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand
⨯
Tanaporn Uengwetwanit,

Roles Methodology, Visualization, Writing – original draft

Affiliation Advanced Diagnostics and Biomarker Discovery Research Team, Biosensing and Bioprospecting Technology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand

https://orcid.org/0000-0003-4710-2613

⨯
Umaporn Uawisetwathana,

Roles Methodology, Visualization, Writing – original draft

Affiliation Advanced Diagnostics and Biomarker Discovery Research Team, Biosensing and Bioprospecting Technology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand
⨯
Pacharaporn Angthong,

Roles Investigation

Affiliation Advanced Diagnostics and Biomarker Discovery Research Team, Biosensing and Bioprospecting Technology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand
⨯
Sopacha Arayamethakorn,

Roles Investigation

Affiliation Advanced Diagnostics and Biomarker Discovery Research Team, Biosensing and Bioprospecting Technology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand
⨯
Phimsucha Bunphimpapha,

Roles Investigation

Affiliation Aquatic Molecular Genetics and Biotechnology Research Team, Integrative Aquaculture Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand
⨯
Panyisa Potibut,

Roles Investigation

Affiliation Aquaculture Service Development Research Team, Integrative Aquaculture Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand
⨯
Waraporn Jangsutthivorawat,

Roles Investigation

Affiliation Aquaculture Service Development Research Team, Integrative Aquaculture Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand
⨯
Virak Visudtiphole,

Roles Investigation

Affiliation Advanced Diagnostics and Biomarker Discovery Research Team, Biosensing and Bioprospecting Technology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand
⨯
Sage Chaiyapechara,

Roles Investigation, Writing – review & editing

Affiliation Aquaculture Service Development Research Team, Integrative Aquaculture Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand
⨯
Wanilada Rungrassamee

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: wanilada.run@biotec.or.th

Affiliation Advanced Diagnostics and Biomarker Discovery Research Team, Biosensing and Bioprospecting Technology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Development Agency, Pathum Thani, Thailand

https://orcid.org/0000-0002-5802-4342

⨯

The innate immune IMD pathway is a key regulator of gut microbiome and metabolic homeostasis in the black tiger shrimp (Penaeus monodon)

Premruethai Supungul,
Sureerat Tang,
Tanaporn Uengwetwanit,
Umaporn Uawisetwathana,
Pacharaporn Angthong,
Sopacha Arayamethakorn,
Phimsucha Bunphimpapha,
Panyisa Potibut,
Waraporn Jangsutthivorawat,
Virak Visudtiphole

Published: December 16, 2025
https://doi.org/10.1371/journal.pone.0338796

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