Impact of MED12 mutation and CDK8 activity on uterine leiomyoma growth and response to gonadotropin-releasing hormone agonist treatment

Saki Tanioka; Ryoko Asano; Yukihide Ota; Koichi Nagai; Katsuya Takenaka; Taichi Mizushima; Yohei Miyagi; Etsuko Miyagi

doi:10.1371/journal.pone.0338485

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Open Access

Peer-reviewed

Research Article

Impact of MED12 mutation and CDK8 activity on uterine leiomyoma growth and response to gonadotropin-releasing hormone agonist treatment

Saki Tanioka,

Roles Investigation, Writing – original draft

Affiliation Department of Obstetrics, Gynecology and Molecular Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan

https://orcid.org/0009-0000-5205-4789

⨯
Ryoko Asano ,

Roles Conceptualization, Writing – review & editing

* E-mail: new_official_asano@hotmail.co.jp

Affiliations Department of Obstetrics, Gynecology and Molecular Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan, Department of Gynecology, Yokohama City University Medical Center, Yokohama, Japan

https://orcid.org/0000-0001-5091-3893

⨯
Yukihide Ota,

Roles Methodology

Affiliation Department of Obstetrics, Gynecology and Molecular Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯
Koichi Nagai,

Roles Funding acquisition, Resources

Affiliation Department of Obstetrics, Gynecology and Molecular Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan

https://orcid.org/0000-0002-0230-1179

⨯
Katsuya Takenaka,

Roles Resources

Affiliations Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan, TR Company, Shin Nippon Biomedical Laboratories, Ltd., Kagoshima, Japan
⨯
Taichi Mizushima,

Roles Writing – review & editing

Affiliation Department of Obstetrics, Gynecology and Molecular Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan

https://orcid.org/0000-0002-3505-4717

⨯
Yohei Miyagi,

Roles Methodology, Writing – review & editing

Affiliation Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
⨯
Etsuko Miyagi

Roles Supervision

Affiliation Department of Obstetrics, Gynecology and Molecular Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯

Impact of MED12 mutation and CDK8 activity on uterine leiomyoma growth and response to gonadotropin-releasing hormone agonist treatment

Saki Tanioka,
Ryoko Asano,
Yukihide Ota,
Koichi Nagai,
Katsuya Takenaka,
Taichi Mizushima,
Yohei Miyagi,
Etsuko Miyagi

Published: January 6, 2026
https://doi.org/10.1371/journal.pone.0338485

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